PMID- 8181854
OWN - NLM
STAT- MEDLINE
DCOM- 19940616
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 57
IP  - 4
DP  - 1994 May 15
TI  - Epidermal-growth-factor-receptor expression is associated with rapid tumor 
      proliferation in bladder cancer.
PG  - 508-14
AB  - Epidermal-growth-factor-receptor (EGF-r) expression has been proposed as a 
      prognostic marker in bladder cancer and is associated with rapid proliferation in 
      cell lines. Ninety-three fresh and 74 formalin-fixed bladder tumors were examined 
      by fluorescence in situ hybridization (FISH) and immunohistochemistry to assess 
      the relationship between EGF-r expression and proliferation as well as the 
      prevalence of epidermal-growth-factor-receptor (EGF-r) gene amplification. EGF-r 
      expression was strongly associated with BUdr labeling index, grade and stage. 
      EGF-r expression emerged as a stronger predictor of tumor proliferation than 
      grade or stage in analysis of variance. Rapid tumor proliferation might be 
      responsible for bad prognosis reported in EGF-r positive bladder tumors. Also 
      chromosome 7 copy number was associated with grade and stage. EGF-r gene 
      amplification was uncommon (5 of 107 tumors). However, FISH analysis allowed 
      characterization of the pattern of amplification, with clustering of signals 
      suggestive of intrachromosomal amplification more common than diffuse 
      distribution consistent with extrachromosomal amplification.
FAU - Sauter, G
AU  - Sauter G
AD  - Department of Laboratory Medicine, University of California, San Francisco.
FAU - Haley, J
AU  - Haley J
FAU - Chew, K
AU  - Chew K
FAU - Kerschmann, R
AU  - Kerschmann R
FAU - Moore, D
AU  - Moore D
FAU - Carroll, P
AU  - Carroll P
FAU - Moch, H
AU  - Moch H
FAU - Gudat, F
AU  - Gudat F
FAU - Mihatsch, M J
AU  - Mihatsch MJ
FAU - Waldman, F
AU  - Waldman F
LA  - eng
GR  - CA47537/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
GS  - EGF-r
MH  - Bromodeoxyuridine/metabolism
MH  - Carcinoma, Papillary/pathology/ultrastructure
MH  - Cell Division/physiology
MH  - Centromere/physiology
MH  - Chromosomes, Human, Pair 17
MH  - ErbB Receptors/genetics/*physiology
MH  - Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Neoplasm Recurrence, Local/pathology/ultrastructure
MH  - Neoplasm Staging
MH  - Urinary Bladder Neoplasms/*pathology/*ultrastructure
EDAT- 1994/05/15 00:00
MHDA- 1994/05/15 00:01
CRDT- 1994/05/15 00:00
PHST- 1994/05/15 00:00 [pubmed]
PHST- 1994/05/15 00:01 [medline]
PHST- 1994/05/15 00:00 [entrez]
AID - 10.1002/ijc.2910570412 [doi]
PST - ppublish
SO  - Int J Cancer. 1994 May 15;57(4):508-14. doi: 10.1002/ijc.2910570412.