PMID- 8182229
OWN - NLM
STAT- MEDLINE
DCOM- 19940616
LR  - 20220331
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 93
IP  - 5
DP  - 1994 May
TI  - Expression of transforming growth factors-alpha and beta 1 messenger RNA and 
      product by eosinophils in nasal polyps.
PG  - 864-9
AB  - Nasal polyps are thought to develop as a manifestation of a chronic inflammatory 
      process involving the upper airways. The eosinophil characteristically represents 
      a prominent component of the inflammatory cell infiltrate of these lesions. 
      However, the major clinical problem associated with nasal polyps, nasal 
      obstruction, reflects the proliferation of the stromal and epithelial elements, 
      which constitute the bulk of these lesions. We recently reported that blood 
      eosinophils of patients with hypereosinophilia can produce the cytokines 
      transforming growth factors-alpha (TGF-alpha) and beta 1 (TGF-beta 1). These 
      cytokines have many biologic activities, which include the regulation of 
      epithelial proliferation, the promotion of extracellular matrix formation, and 
      the induction of angiogenesis. We therefore used in situ hybridization to 
      determine whether the eosinophils that infiltrate nasal polyps express TGF-alpha 
      and/or TGF-beta 1 messenger RNA and used immunohistochemistry to determine 
      whether these eosinophils also express TGF-alpha and TGF-beta 1 proteins. We 
      found that eosinophils represented a major source of both transforming growth 
      factors in each case of nasal polyposis examined and that in most cases the 
      majority of all eosinophils expressed both TGF-alpha and TGF-beta 1. These 
      results suggest that production of TGF-alpha and TGF-beta 1 by the infiltrating 
      eosinophils may contribute to some of the pathologic changes observed in nasal 
      polyposis, such as thickening of the epithelial basement membrane, stromal 
      fibrosis, angiogenesis, and epithelial and glandular hyperplasia.
FAU - Elovic, A
AU  - Elovic A
AD  - Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental 
      Medicine, Boston, MA 02115.
FAU - Wong, D T
AU  - Wong DT
FAU - Weller, P F
AU  - Weller PF
FAU - Matossian, K
AU  - Matossian K
FAU - Galli, S J
AU  - Galli SJ
LA  - eng
GR  - AI-22674/AI/NIAID NIH HHS/United States
GR  - DE-08680/DE/NIDCR NIH HHS/United States
GR  - DE-10335/DE/NIDCR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Aniline Compounds)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Rhodamines)
RN  - 0 (Transforming Growth Factor alpha)
RN  - 0 (Transforming Growth Factor beta)
RN  - 8004-91-9 (aniline blue)
SB  - IM
MH  - *Aniline Compounds
MH  - Eosinophils/*metabolism
MH  - Fluorescence
MH  - Fluorescent Dyes
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Nasal Polyps/*metabolism
MH  - Proteins/*metabolism
MH  - RNA, Messenger/*metabolism
MH  - Rhodamines
MH  - Transforming Growth Factor alpha/*metabolism
MH  - Transforming Growth Factor beta/*metabolism
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 0091-6749(94)90379-4 [pii]
AID - 10.1016/0091-6749(94)90379-4 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 1994 May;93(5):864-9. doi: 10.1016/0091-6749(94)90379-4.