PMID- 8182448
OWN - NLM
STAT- MEDLINE
DCOM- 19940614
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 14
IP  - 5 Pt 1
DP  - 1994 May
TI  - The differential control of c-jun expression in regenerating sensory neurons and 
      their associated glial cells.
PG  - 2911-23
AB  - Damage to the axons of adult sensory neurons results in massively increased 
      expression of the protooncogene c-jun both in neurons and in the associated 
      Schwann cells. The role of growth factors and axon contact in mediating this 
      expression was investigated in dissociated cultures of adult sensory neurons and 
      glial cells that expressed c-jun within 24 hr of plating. Trk, trkB, and trkC 
      growth factor receptor genes were expressed in discrete subpopulations of sensory 
      neurons but addition of NGF or brain-derived neurotrophic factor (BDNF) did not 
      inhibit the expression of c-jun. Similarly, axon contact was not sufficient to 
      decrease c-jun expression in glial cells. However, c-jun expression could be 
      downregulated in glial cells, but not neurons, by treatment with cAMP or 
      forskolin and increased by raising intracellular calcium levels. The results 
      suggest that c-jun levels are differentially regulated in neurons and glial cells 
      but that NGF or BDNF do not regulate c-jun expression in damaged neurons.
FAU - De Felipe, C
AU  - De Felipe C
AD  - MRC Laboratory of Molecular Biology, Division of Neurobiology, Cambridge, United 
      Kingdom.
FAU - Hunt, S P
AU  - Hunt SP
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antibodies)
RN  - 0 (Cytokines)
RN  - 0 (Growth Substances)
RN  - 0 (Oligopeptides)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (oncogene protein trk)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
GS  - c-jun
GS  - trk
GS  - trkB
GS  - trkC
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies
MH  - Cells, Cultured
MH  - Cytokines/pharmacology
MH  - Fluorescent Antibody Technique
MH  - Ganglia, Spinal/cytology/metabolism/*physiology
MH  - *Gene Expression/drug effects
MH  - *Genes, jun
MH  - Growth Substances/pharmacology
MH  - Immunohistochemistry
MH  - Molecular Sequence Data
MH  - *Nerve Regeneration
MH  - Neuroglia/cytology/metabolism/*physiology
MH  - Neurons, Afferent/cytology/metabolism/*physiology
MH  - Oligopeptides/immunology
MH  - Oncogene Proteins/biosynthesis
MH  - Proto-Oncogene Proteins c-jun/*biosynthesis
MH  - RNA, Messenger/analysis/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/biosynthesis
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptor, trkC
MH  - Receptors, Growth Factor/*biosynthesis
MH  - Sciatic Nerve/*physiology
PMC - PMC6577506
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
PMCR- 1994/11/01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
PHST- 1994/11/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.14-05-02911.1994 [doi]
PST - ppublish
SO  - J Neurosci. 1994 May;14(5 Pt 1):2911-23. doi: 10.1523/JNEUROSCI.14-05-02911.1994.