PMID- 8183185
OWN - NLM
STAT- MEDLINE
DCOM- 19940616
LR  - 20190920
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 16
IP  - 1
DP  - 1994 Jan-Feb
TI  - Effect of prenatal cocaine on the acquisition of cocaine-induced taste aversions.
PG  - 17-23
AB  - Pregnant Long-Evans rats were injected SC twice daily with 20 mg/kg cocaine from 
      gestational days (GD) 7-19. Vehicle controls were administered distilled water on 
      these days. Pair-fed controls were similarly treated but allowed the same amount 
      of food as consumed by the cocaine-exposed mothers. On postnatal day 1 (PND 1), 
      pups of the mothers exposed to cocaine were surrogate-fostered. On PND 41, all 
      subjects were grouped according to their history (cocaine, vehicle, and pair-fed) 
      and were tested for their behavioral sensitivity to the aversive effects of 
      cocaine by assessing their ability to acquire a cocaine-induced taste aversion. 
      Rats from all three conditions were given saccharin to drink and then injected SC 
      with either 0, 18, 32, or 50 mg/kg cocaine. Prenatal exposure to cocaine had no 
      effect on the acquisition of aversions. Specifically, the prenatally exposed 
      animals acquired the taste aversion in a dose-dependent manner similar to that of 
      the controls. These data indicate that changes in sensitivity to cocaine are not 
      necessary consequences of prenatal cocaine exposure.
FAU - Ferrari, C M
AU  - Ferrari CM
AD  - Department of Psychology, American University, Washington, DC 20016.
FAU - Riley, A L
AU  - Riley AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - FST467XS7D (Saccharin)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Cocaine/administration & dosage/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Injections, Subcutaneous
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Saccharin/pharmacology
MH  - Sex Characteristics
MH  - Taste/*drug effects
MH  - Weight Gain/drug effects
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1016/0892-0362(94)90004-3 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1994 Jan-Feb;16(1):17-23. doi: 
      10.1016/0892-0362(94)90004-3.