PMID- 8185148
OWN - NLM
STAT- MEDLINE
DCOM- 19940616
LR  - 20190619
IS  - 0003-4819 (Print)
IS  - 0003-4819 (Linking)
VI  - 120
IP  - 12
DP  - 1994 Jun 15
TI  - Fasciitis in chronic graft-versus-host disease. A clinicopathologic study of 14 
      cases.
PG  - 993-8
AB  - OBJECTIVE: To describe the clinicopathologic features of fasciitis in patients 
      with chronic graft-versus-host disease (GVHD) after allogeneic bone marrow 
      transplantation from human leukocyte antigen (HLA)-identical donors. DESIGN: A 
      retrospective cohort study. SETTING: Tertiary care center. PATIENTS: Patients who 
      had allogeneic bone marrow transplantation and developed chronic GVHD with 
      clinical and pathologic signs of fasciitis. MAIN OUTCOME MEASURE: Analysis of 
      clinical presentations and of deep cutaneo-muscular biopsy specimens. RESULTS: 
      Between January 1974 and January 1991, 14 of 475 patients who had allogeneic bone 
      marrow transplantation developed chronic GVHD that began with the sicca syndrome 
      and liver or digestive tract involvement, or both, 60 to 170 days after the graft 
      was received. Sudden and painful skin swelling was reported 350 to 3745 days 
      after the graft was received. Follow-up over 2 to 7 years showed failure of the 
      fasciitis to respond to steroid therapy or to any conventional treatment of 
      chronic GVHD. Although 7 patients showed moderate improvement, the others 
      remained functionally disabled because of skin tightness, joint stiffness, 
      contractures, and sores. Patients with fasciitis in chronic GVHD had no specific 
      immunogenetic profile and no history of L-tryptophan intake or phytonadione 
      injections. CONCLUSION: Among alloimmune syndromes, fasciitis is a distinct 
      entity that leads to functional disability. This rare form of chronic GVHD may 
      provide clues to understanding the mechanisms involved in fasciitis from other 
      causes.
FAU - Janin, A
AU  - Janin A
AD  - Hopital Calmette, Lile, France.
FAU - Socie, G
AU  - Socie G
FAU - Devergie, A
AU  - Devergie A
FAU - Aractingi, S
AU  - Aractingi S
FAU - Esperou, H
AU  - Esperou H
FAU - Verola, O
AU  - Verola O
FAU - Gluckman, E
AU  - Gluckman E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Ann Intern Med. 1995 Jan 15;122(2):155-6. PMID: 7864973
MH  - Adolescent
MH  - Adult
MH  - Biopsy
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Child
MH  - Chronic Disease
MH  - Edema/pathology
MH  - Fasciitis/drug therapy/etiology/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/*complications/drug therapy/pathology
MH  - HLA Antigens
MH  - Histocompatibility
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 1994/06/15 00:00
MHDA- 1994/06/15 00:01
CRDT- 1994/06/15 00:00
PHST- 1994/06/15 00:00 [pubmed]
PHST- 1994/06/15 00:01 [medline]
PHST- 1994/06/15 00:00 [entrez]
AID - 10.7326/0003-4819-120-12-199406150-00004 [doi]
PST - ppublish
SO  - Ann Intern Med. 1994 Jun 15;120(12):993-8. doi: 
      10.7326/0003-4819-120-12-199406150-00004.