PMID- 8187550
OWN - NLM
STAT- MEDLINE
DCOM- 19940622
LR  - 20191210
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 67
IP  - 1
DP  - 1994
TI  - Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 
      (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26-->p25 and Xq28, respectively.
PG  - 41-5
AB  - The plasma membrane Ca2+ ATPases (PMCA) represent a highly conserved, widely 
      dispersed, multigene family in eukaryotes consisting of at least four functional 
      genes. The genes for PMCA isoforms 1 and 4 (ATP2B1 and ATP2B4) have been 
      previously localized to human chromosomes 12q21-->q23 and 1q25-->q32, 
      respectively. Based upon results of fluorescence in situ hybridization (FISH), 
      analysis of somatic cell hybrids, and genetic linkage analyses, we now report 
      localization of ATP2B3 (PMCA isoform 3) to human chromosome Xq28, and confirm the 
      recent localization of ATP2B2 (PMCA isoform 2) to chromosome 3p26-->p25. In 
      contrast to ATP2B1 and ATP2B4, recent studies have suggested tissue specific 
      regulation of expression of both ATP2B2 and ATP2B3 particularly in the nervous 
      system. The genes for several neurological and neuromuscular diseases have been 
      assigned to the distal portion of Xq, and ATP2B3 is a candidate gene for these 
      diseases.
FAU - Wang, M G
AU  - Wang MG
AD  - Laboratory of Biochemistry, National Cancer Institute, National Institutes of 
      Health, Bethesda, MD 20892.
FAU - Yi, H
AU  - Yi H
FAU - Hilfiker, H
AU  - Hilfiker H
FAU - Carafoli, E
AU  - Carafoli E
FAU - Strehler, E E
AU  - Strehler EE
FAU - McBride, O W
AU  - McBride OW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Isoenzymes)
RN  - EC 7.2.2.10 (Calcium-Transporting ATPases)
SB  - IM
GS  - ATP2B2
GS  - ATP2B3
MH  - Calcium-Transporting ATPases/*genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 3
MH  - Genes
MH  - Genetic Linkage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Isoenzymes/genetics
MH  - X Chromosome
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1159/000133794 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1994;67(1):41-5. doi: 10.1159/000133794.