PMID- 8194041
OWN - NLM
STAT- MEDLINE
DCOM- 19940624
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 74
IP  - 1
DP  - 1994 May
TI  - Interphase molecular cytogenetics of Ewing's sarcoma and peripheral 
      neuroepithelioma t(11;22) with flanking and overlapping cosmid probes.
PG  - 13-8
AB  - The translocation, t(11;22)(q24;q12), recurrently observed in Ewing's sarcoma and 
      in peripheral neuroepithelioma has been recently cloned. The analysis of a series 
      of ES/PNE has revealed that the chromosome 22 breakpoints are clustered in a 
      small region of 7 kb, called EWSR1, and that those on chromosome 11 are spread 
      over a larger region of 40-50 kb, called EWSR2. Cosmids from loci flanking or 
      overlapping these two regions have been obtained. We demonstrate here that 
      fluorescence in situ hybridization (FISH) with these cosmids allows the 
      localization of the two breakpoints with a 10-kb resolution and leads to a rapid 
      and reliable ES/PNE diagnosis.
FAU - Desmaze, C
AU  - Desmaze C
AD  - Laboratoire de Genetique des Tumeurs, INSERM CJF 9201, Institut Curie, Paris, 
      France.
FAU - Zucman, J
AU  - Zucman J
FAU - Delattre, O
AU  - Delattre O
FAU - Melot, T
AU  - Melot T
FAU - Thomas, G
AU  - Thomas G
FAU - Aurias, A
AU  - Aurias A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Cell Line
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 22
MH  - Cosmids
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Neuroectodermal Tumors, Primitive, Peripheral/*genetics
MH  - Sarcoma, Ewing/*genetics
MH  - *Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 0165-4608(94)90022-1 [pii]
AID - 10.1016/0165-4608(94)90022-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 May;74(1):13-8. doi: 10.1016/0165-4608(94)90022-1.