PMID- 8194491
OWN - NLM
STAT- MEDLINE
DCOM- 19940628
LR  - 20061115
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 134
IP  - 6
DP  - 1994 Jun
TI  - The retinoic acid and retinoid X receptors are differentially expressed during 
      myoblast differentiation.
PG  - 2658-61
AB  - Retinoids (all trans and 9-cis retinoic acid) are pleiotropic regulators of cell 
      fate, and have been shown to regulate the expression of helix loop helix 
      transcription factors (e.g MyoD, myogenin and Myf-5) that control myogenic 
      differentiation. The effects of retinoids are mediated through the ligand 
      dependent retinoic acid receptors (RARs) and retinoid X receptors (RXRs). We have 
      found that the messenger RNA transcripts encoding RAR are repressed during 
      differentiation of C2C12 myoblasts while, conversely, RXR mRNA transcripts are 
      induced in C2C12 myotubes. These results imply that RXRs, play a major regulatory 
      role in differentiated muscle.
FAU - Downes, M
AU  - Downes M
AD  - University of Queensland, Centre for Molecular Biology and Biotechnology, Ritchie 
      Research Laboratories, St. Lucia, Australia.
FAU - Mynett-Johnson, L
AU  - Mynett-Johnson L
FAU - Muscat, G E
AU  - Muscat GE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - *Cell Differentiation
MH  - Cell Line
MH  - *Gene Expression
MH  - Mice
MH  - Muscles/*cytology
MH  - RNA, Messenger/metabolism
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoid X Receptors
MH  - *Transcription Factors
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1210/endo.134.6.8194491 [doi]
PST - ppublish
SO  - Endocrinology. 1994 Jun;134(6):2658-61. doi: 10.1210/endo.134.6.8194491.