PMID- 8195608
OWN - NLM
STAT- MEDLINE
DCOM- 19940630
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 169
IP  - 6
DP  - 1994 Jun
TI  - Patterns of proinflammatory cytokines and inhibitors during typhoid fever.
PG  - 1306-11
AB  - Cytokines and inhibitors in plasma were measured in 44 patients with typhoid 
      fever. Ex vivo production of the cytokines was analyzed in a whole blood culture 
      system with and without lipopolysaccharide (LPS). Acute phase circulating 
      concentrations of cytokines (+/- SD) were as follows: interleukin (IL)-1 beta, < 
      140 pg/mL; tumor necrosis factor-alpha (TNF alpha), 130 +/- 50 pg/mL; IL-6, 96 
      +/- 131 pg/mL; and IL-8, 278 +/- 293 pg/mL. Circulating inhibitors were elevated 
      in the acute phase: IL-1 receptor antagonist (IL-1RA) was 2304 +/- 1427 pg/mL and 
      soluble TNF receptors 55 and 75 were 4973 +/- 2644 pg/mL and 22,865 +/- 15,143 
      pg/mL, respectively. LPS-stimulated production of cytokines was lower during the 
      acute phase than during convalescence (mean values: IL-1 beta, 2547 vs. 6576 
      pg/mL; TNF alpha, 2609 vs. 6338 pg/mL; IL-6, 2416 vs. 7713 pg/mL). LPS-stimulated 
      production of IL-1RA was higher in the acute than during the convalescent phase 
      (5608 vs. 3977 pg/mL). Inhibited production of cytokines during the acute phase 
      may be due to a switch from a proinflammatory to an antiinflammatory mode.
FAU - Keuter, M
AU  - Keuter M
AD  - University Hospital, Nijmegen, Netherlands.
FAU - Dharmana, E
AU  - Dharmana E
FAU - Gasem, M H
AU  - Gasem MH
FAU - van der Ven-Jongekrijg, J
AU  - van der Ven-Jongekrijg J
FAU - Djokomoeljanto, R
AU  - Djokomoeljanto R
FAU - Dolmans, W M
AU  - Dolmans WM
FAU - Demacker, P
AU  - Demacker P
FAU - Sauerwein, R
AU  - Sauerwein R
FAU - Gallati, H
AU  - Gallati H
FAU - van der Meer, J W
AU  - van der Meer JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Cytokines)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Cytokines/antagonists & inhibitors/*blood
MH  - Female
MH  - Humans
MH  - Inflammation/immunology
MH  - Male
MH  - Typhoid Fever/*immunology
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1093/infdis/169.6.1306 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Jun;169(6):1306-11. doi: 10.1093/infdis/169.6.1306.