PMID- 8195677
OWN - NLM
STAT- MEDLINE
DCOM- 19940629
LR  - 20061115
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 123
IP  - 5
DP  - 1994 May
TI  - Latex allergy: frequent occurrence of IgE antibodies to a cluster of 11 latex 
      proteins in patients with spina bifida and histories of anaphylaxis.
PG  - 712-20
AB  - Proteins and allergens in natural rubber latex were characterized by a 
      two-dimensional immunoblot method with serum samples from 17 patients with latex 
      allergy of whom 10 had spina bifida and 7 were health care workers. We 
      demonstrated in rubber tree sap approximately 240 polypeptides of which 57 bound 
      immunoglobulin E (IgE) in patient serum samples. Forty-six of the 57 allergens 
      were identified by patients with spina bifida, 19 of 57 allergens by health care 
      workers, and 8 of 57 allergens by both patient groups. IgE antibodies from all 5 
      patients with spina bifida with histories of anaphylaxis bound three allergens 
      with molecular weights of 27 kd and isoelectric points ranging from pH 4.6 to pH 
      4.8. Four of these 5 patients also identified a complex of eight other allergens 
      with molecular weights ranging from 13 kd to 27 kd and isoelectric points from pH 
      4.4 to pH 5.6. This cluster of 11 allergens was identified by none of the 7 
      health care workers and by only 1 of 5 patients with spina bifida without 
      demonstrable anaphylaxis. These preliminary findings indicate that patients with 
      spina bifida in whom latex hypersensitivity has developed exhibit a strong 
      anti-latex IgE immune response, which seems to differ markedly from the immune 
      response of health care workers with latex allergy. The characteristic anti-latex 
      IgE profile in patients with spina bifida and with a history of an anaphylactic 
      reaction may be valuable in the evaluation of pathogenetic processes in latex 
      allergy.
FAU - Alenius, H
AU  - Alenius H
AD  - Department of Medicine, Medical College of Wisconsin, Zablocki Veterans Affairs 
      Medical Center, Milwaukee 53295-1000.
FAU - Kurup, V
AU  - Kurup V
FAU - Kelly, K
AU  - Kelly K
FAU - Palosuo, T
AU  - Palosuo T
FAU - Turjanmaa, K
AU  - Turjanmaa K
FAU - Fink, J
AU  - Fink J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - 0 (Antibodies)
RN  - 0 (Antigens)
RN  - 0 (Latex)
RN  - 0 (Plant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anaphylaxis/*complications
MH  - Antibodies/*analysis
MH  - Antigens/chemistry/immunology
MH  - Child
MH  - Child, Preschool
MH  - Drug Hypersensitivity/*immunology
MH  - Electrophoresis, Gel, Two-Dimensional
MH  - Female
MH  - Humans
MH  - Immunoblotting
MH  - Immunoglobulin E/*analysis
MH  - *Latex
MH  - Male
MH  - Medical Records
MH  - Molecular Weight
MH  - Plant Proteins/*immunology
MH  - Spinal Dysraphism/*complications/*immunology
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
PST - ppublish
SO  - J Lab Clin Med. 1994 May;123(5):712-20.