PMID- 8195680
OWN - NLM
STAT- MEDLINE
DCOM- 19940629
LR  - 20071114
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 123
IP  - 5
DP  - 1994 May
TI  - Aspergillus ribotoxins react with IgE and IgG antibodies of patients with 
      allergic bronchopulmonary aspergillosis.
PG  - 749-56
AB  - Asp f I has been identified as a major allergen of Aspergillus fumigatus and 
      shows amino acid sequence homology with the mitogillin family of cytotoxins. In 
      this study we compared the various cytotoxins from Aspergillus species for their 
      reactivity with immunoglobulin E (IgE) and immunoglobulin G (IgG) antibodies in 
      the serum samples of patients with allergic bronchopulmonary aspergillosis. 
      Elevated levels of IgE and IgG antibodies to all A. fumigatus antigens and 
      ribotoxins were demonstrated in a majority of ABPA patients as compared with 
      allergic patients with asthma and normal subjects. In approximately 75% of 
      patients with allergic aspergillosis, IgE antibody to ribotoxins showed marked 
      elevation, whereas in the remaining patients it was below the baseline, although 
      crude A. fumigatus antigen showed higher specific serum IgE. These results 
      suggest that cytotoxins play a major role in the pathogenesis of allergic 
      bronchopulmonary aspergillosis.
FAU - Kurup, V P
AU  - Kurup VP
AD  - Department of Medicine, Medical College of Wisconsin, V.A. Medical Center, 
      Milwaukee.
FAU - Kumar, A
AU  - Kumar A
FAU - Kenealy, W R
AU  - Kenealy WR
FAU - Greenberger, P A
AU  - Greenberger PA
LA  - eng
GR  - AI 11403/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - 0 (Antibodies)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Cytotoxins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Mycotoxins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies/analysis/*immunology
MH  - Antigens, Fungal/immunology
MH  - Aspergillosis, Allergic Bronchopulmonary/*immunology
MH  - Aspergillus fumigatus/*metabolism
MH  - Asthma/etiology/immunology
MH  - Blotting, Western
MH  - Cytotoxins/immunology
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Hypersensitivity/complications
MH  - Immunoglobulin E/*immunology
MH  - Immunoglobulin G/*immunology
MH  - Mycotoxins/*immunology
MH  - Reference Values
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
PST - ppublish
SO  - J Lab Clin Med. 1994 May;123(5):749-56.