PMID- 8195724
OWN - NLM
STAT- MEDLINE
DCOM- 19940627
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 179
IP  - 6
DP  - 1994 Jun 1
TI  - Frequency of immunoglobulin E class switching is autonomously determined and 
      independent of prior switching to other classes.
PG  - 2023-6
AB  - Both, in humans and in mice, a major fraction of immunoglobulin E 
      (IgE)-expressing B lymphocytes develops by sequential Ig class switching from IgM 
      via IgG to IgE. This sequential class switch might have functional implications 
      for the frequency and repertoire of IgE+ cells. Here we show that in mutant mice, 
      in which sequential switching to IgE via IgG1 is blocked, the frequency of cells 
      switching to IgE is not affected. Thus, sequential class switching to IgE merely 
      reflects the simultaneous accessibility of two acceptor switch regions for switch 
      recombination, induced by one cytokine, but with markedly distinct efficiency. 
      Analysis of switch recombination on both IgH alleles of switched cells shows that 
      the low frequency of switching to IgE is an inherent feature of the S epsilon 
      switch region and its control elements.
FAU - Jung, S
AU  - Jung S
AD  - Institute for Genetics, University of Cologne, Germany.
FAU - Siebenkotten, G
AU  - Siebenkotten G
FAU - Radbruch, A
AU  - Radbruch A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin Isotypes)
RN  - 0 (Immunoglobulin M)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/*immunology
MH  - Cells, Cultured
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Gene Rearrangement
MH  - *Genes, Immunoglobulin
MH  - *Genes, Switch
MH  - Homozygote
MH  - Humans
MH  - Immunoglobulin E/biosynthesis/*genetics
MH  - Immunoglobulin G/biosynthesis/genetics
MH  - Immunoglobulin Isotypes/biosynthesis/genetics
MH  - Immunoglobulin M/biosynthesis/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred Strains
MH  - Mice, Mutant Strains
MH  - Restriction Mapping
MH  - Species Specificity
PMC - PMC2191511
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
PMCR- 1994/12/01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
PHST- 1994/12/01 00:00 [pmc-release]
AID - 94253743 [pii]
AID - 10.1084/jem.179.6.2023 [doi]
PST - ppublish
SO  - J Exp Med. 1994 Jun 1;179(6):2023-6. doi: 10.1084/jem.179.6.2023.