PMID- 8197314
OWN - NLM
STAT- MEDLINE
DCOM- 19940627
LR  - 20191210
IS  - 0033-3174 (Print)
IS  - 0033-3174 (Linking)
VI  - 56
IP  - 1
DP  - 1994 Jan-Feb
TI  - Hostile behavior during marital conflict alters pituitary and adrenal hormones.
PG  - 41-51
AB  - We evaluated hormonal changes and problem-solving behaviors in 90 newlywed 
      couples who were admitted to a hospital research unit for 24 hours. The subjects 
      were selected on the basis of stringent mental and physical health criteria, and 
      admissions were scheduled during the follicular phase of the woman's menstrual 
      cycle. For frequent, unobtrusive endocrine sampling during the interaction tasks, 
      a long polyethylene tube was attached to a heparin well, allowing nurses to draw 
      blood samples at set intervals, out of subjects' sight. Five blood samples were 
      obtained before, during, and after a 30-minute structured problem-solving or 
      conflict task. The conflict session was recorded on videotapes that were later 
      scored for problem-solving behaviors using the Marital Interaction Coding System 
      (MICS). Marital conflict and MICS-coded hostile or negative behavior during 
      conflict was closely linked to changes in serum hormonal levels across five of 
      the six hormones we studied, in spite of the high marital satisfaction of our 
      newlywed couples and the healthy lifestyles demanded by our exclusion criteria. 
      Hostile behavior was associated with decreased levels of prolactin (PRL) and 
      increases in epinephrine (EPI), norepinephrine (NEPI), ACTH, and growth hormone 
      (GH), but not cortisol. These data suggest that the endocrine system may be an 
      important mediator between personal relationships and health.
FAU - Malarkey, W B
AU  - Malarkey WB
AD  - Department of Internal Medicine, Ohio State University Medical Center, Columbus.
FAU - Kiecolt-Glaser, J K
AU  - Kiecolt-Glaser JK
FAU - Pearl, D
AU  - Pearl D
FAU - Glaser, R
AU  - Glaser R
LA  - eng
GR  - MH44660/MH/NIMH NIH HHS/United States
GR  - MO1-RR-0034/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Psychosom Med
JT  - Psychosomatic medicine
JID - 0376505
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - 9002-72-6 (Growth Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Adult
MH  - Affect/physiology
MH  - Arousal/*physiology
MH  - *Conflict, Psychological
MH  - Epinephrine/blood
MH  - Female
MH  - Growth Hormone/blood
MH  - *Hostility
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Male
MH  - Marriage/*psychology
MH  - Norepinephrine/blood
MH  - Personality Assessment
MH  - Pituitary-Adrenal System/*physiopathology
MH  - Problem Solving/physiology
MH  - Prolactin/blood
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1097/00006842-199401000-00006 [doi]
PST - ppublish
SO  - Psychosom Med. 1994 Jan-Feb;56(1):41-51. doi: 10.1097/00006842-199401000-00006.