PMID- 8197848
OWN - NLM
STAT- MEDLINE
DCOM- 19940624
LR  - 20190821
IS  - 0001-6470 (Print)
IS  - 0001-6470 (Linking)
VI  - 65
IP  - 2
DP  - 1994 Apr
TI  - T-lymphocytes are not necessary for particulate polyethylene-induced macrophage 
      recruitment. Histologic studies of the rat tibia.
PG  - 157-60
AB  - Immunological processes involving T-lymphocytes have been implicated in the 
      mechanisms of aseptic loosening of joint endoprostheses. We report the 
      histological reaction of bone to phagocytosable particles of high-density 
      polyethylene (HDPE) in normal and T-cell deficient rats. A bolus of 3 x 10(7) 
      polyethylene particles averaging 4.7 microns in size, mixed in 0.1 mL of sodium 
      hyaluronate, was injected into the right proximal tibia of 10 normal and 10 
      T-cell deficient (nude) Rowett rats from the same litter. The left control side 
      was injected with sodium hyaluronate alone. The animals were killed after 6 
      weeks. Transverse paraffin-embedded sections stained with hematoxylin and eosin 
      were made of the implant area. On the control side, there was normal bone marrow 
      without evidence of foreign body reaction. On the HDPE side, in both normal and 
      T-cell deficient rats, macrophages were found to surround and engulf the 
      particles, with no differences in the histological reactions. We conclude that 
      T-lymphocytes are not necessary for the recruitment of macrophages to sites in 
      which phagocytosable particles of HDPE have been implanted.
FAU - Goodman, S
AU  - Goodman S
AD  - Department of Orthopedics, University of Lund, Sweden.
FAU - Wang, J S
AU  - Wang JS
FAU - Regula, D
AU  - Regula D
FAU - Aspenberg, P
AU  - Aspenberg P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Orthop Scand
JT  - Acta orthopaedica Scandinavica
JID - 0370352
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyethylenes)
SB  - IM
MH  - Animals
MH  - *Biocompatible Materials
MH  - Cell Movement/immunology
MH  - Foreign-Body Reaction/etiology/*immunology/*pathology
MH  - Joint Prosthesis
MH  - Macrophages/*immunology
MH  - Polyethylenes/*adverse effects
MH  - Prostheses and Implants/adverse effects
MH  - Prosthesis Failure
MH  - Rats
MH  - Rats, Nude
MH  - T-Lymphocytes/*immunology
MH  - Tibia/*pathology
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.3109/17453679408995425 [doi]
PST - ppublish
SO  - Acta Orthop Scand. 1994 Apr;65(2):157-60. doi: 10.3109/17453679408995425.