PMID- 8199030
OWN - NLM
STAT- MEDLINE
DCOM- 19940701
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 86
IP  - 2
DP  - 1994 Feb
TI  - Adult T-cell leukaemia/lymphoma featuring a large granular lymphocyte leukaemia 
      morphologically.
PG  - 383-5
AB  - A 70-year-old man from an endemic area of human T-cell lymphotropic virus type I 
      (HTLV-I) developed rapid generalized lymphadenopathy and abdominal tumours. The 
      white blood cell count was 198.3 x 10(9)/l with 93% lymphocytes, 66.3% of which 
      expressed large granular lymphocytes (LGLs). Bone marrow and lymph nodes were 
      also infiltrated by LGLs. Surface markers were positive for CD4, CD25 and HLA-DR, 
      and negative for CD3, CD8, CD16, CD56 and CD57. A monoclonal integration of 
      HTLV-I proviral DNA was demonstrated on these LGLs by Southern blot hybridization 
      analysis. This fact indicates that some adult T-cell leukaemia/lymphoma may 
      morphologically present LGL leukaemia.
FAU - Sakamoto, Y
AU  - Sakamoto Y
AD  - Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
FAU - Kawachi, Y
AU  - Kawachi Y
FAU - Uchida, T
AU  - Uchida T
FAU - Abe, T
AU  - Abe T
FAU - Mori, M
AU  - Mori M
FAU - Setsu, K
AU  - Setsu K
FAU - Indo, N
AU  - Indo N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Aged
MH  - Blotting, Southern
MH  - DNA, Viral/analysis
MH  - Human T-lymphotropic virus 1/genetics/isolation & purification
MH  - Humans
MH  - Leukemia, Lymphoid/microbiology/*pathology
MH  - Leukemia-Lymphoma, Adult T-Cell/complications/*pathology
MH  - Male
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1994.tb04745.x [doi]
PST - ppublish
SO  - Br J Haematol. 1994 Feb;86(2):383-5. doi: 10.1111/j.1365-2141.1994.tb04745.x.