PMID- 8199339
OWN - NLM
STAT- MEDLINE
DCOM- 19940705
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 5
IP  - 6
DP  - 1994 Feb 24
TI  - Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in 
      adult rats.
PG  - 693-6
AB  - In adult mammals, transection of the hypoglossal nerve results in a dramatic loss 
      of choline acetyltransferase (ChAT) in the hypoglossal motor neurons without 
      affecting their cell number. This injury-induced reduction in ChAT is prevented 
      when brain-derived neurotrophic factor (BDNF) is applied to the proximal end of 
      the transected nerve. In contrast, application of ciliary neurotrophic factor 
      (CNTF) has no such effect, even though both factors are known to rescue 
      developing motor neurons from cell death. These results suggest that BDNF may 
      regulate the phenotypic expression of ChAT in mature motor neurons, and indicate 
      that the sensitivity and response of motor neurons to such neurotrophic agents 
      change with development.
FAU - Chiu, A Y
AU  - Chiu AY
AD  - Division of Neurosciences, Beckman Research Institute of the City of Hope Medical 
      Center, Duarte, CA 91010.
FAU - Chen, E W
AU  - Chen EW
FAU - Loera, S
AU  - Loera S
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Death/drug effects
MH  - Choline O-Acetyltransferase/metabolism
MH  - Ciliary Neurotrophic Factor
MH  - Female
MH  - Hypoglossal Nerve/cytology/drug effects/enzymology
MH  - Immunohistochemistry
MH  - Motor Neurons/*drug effects/enzymology/physiology
MH  - Nerve Growth Factors/*pharmacology
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Phenotype
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tongue/innervation
EDAT- 1994/02/24 00:00
MHDA- 1994/02/24 00:01
CRDT- 1994/02/24 00:00
PHST- 1994/02/24 00:00 [pubmed]
PHST- 1994/02/24 00:01 [medline]
PHST- 1994/02/24 00:00 [entrez]
AID - 10.1097/00001756-199402000-00008 [doi]
PST - ppublish
SO  - Neuroreport. 1994 Feb 24;5(6):693-6. doi: 10.1097/00001756-199402000-00008.