PMID- 8200639
OWN - NLM
STAT- MEDLINE
DCOM- 19940701
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 25
IP  - 5
DP  - 1994 May
TI  - Monocyte chemoattractant protein-1 in idiopathic pulmonary fibrosis and other 
      interstitial lung diseases.
PG  - 455-63
AB  - Macrophages play a crucial role in the pathogenesis of idiopathic pulmonary 
      fibrosis (IPF). To examine the mechanisms for increased monocyte/macrophage 
      recruitment in IPF and nonIPF interstitial lung diseases (nonIPF) the 
      localization of monocyte chemoattractant protein-1 (MCP-1) was investigated in 14 
      cases of IPF, seven cases of nonIPF, and seven normal control lungs (CTRL) by 
      immunohistochemistry using a specific anti-MCP-1 monoclonal antibody, F9. By 
      double immunohistochemical staining using F9 and one of the cell type specific 
      antibodies significant differences in the staining pattern of MCP-1 were observed 
      between IPF and nonIPF. In IPF MCP-1 was observed in cuboidal and flattened 
      metaplastic epithelial cells, alveolar macrophages, and vascular endothelial 
      cells. In contrast, no epithelial cells were stained for MCP-1 in nonIPF cases, 
      although alveolar macrophages and vascular endothelial cells were labeled. 
      Northern hybridization analysis of selected cases showed marked expression of 
      MCP-1 messenger RNA (mRNA) in IPF and nonIPF compared with CTRL. These findings 
      suggest that the MCP-1 production in IPF and nonIPF plays an important role in 
      the recruitment of monocyte/macrophages. Monocyte chemoattractant protein-1 
      production by epithelial cells in IPF may be caused by the metaplastic nature of 
      the epithelial cells and may be one of the key factors inducing the irreversible 
      progression of IPF.
FAU - Iyonaga, K
AU  - Iyonaga K
AD  - Second Department of Pathology, Kumamoto University School of Medicine, Japan.
FAU - Takeya, M
AU  - Takeya M
FAU - Saita, N
AU  - Saita N
FAU - Sakamoto, O
AU  - Sakamoto O
FAU - Yoshimura, T
AU  - Yoshimura T
FAU - Ando, M
AU  - Ando M
FAU - Takahashi, K
AU  - Takahashi K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Monoclonal
MH  - Blotting, Northern
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Lung Diseases, Interstitial/*metabolism
MH  - Macrophages, Alveolar/chemistry
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Fibrosis/*metabolism
MH  - RNA, Messenger/analysis
MH  - Up-Regulation
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 0046-8177(94)90117-1 [pii]
AID - 10.1016/0046-8177(94)90117-1 [doi]
PST - ppublish
SO  - Hum Pathol. 1994 May;25(5):455-63. doi: 10.1016/0046-8177(94)90117-1.