PMID- 8201265
OWN - NLM
STAT- MEDLINE
DCOM- 19940707
LR  - 20121115
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 123
IP  - 6
DP  - 1994 Jun
TI  - Immunologic cross-reactivity of acid anhydrides with immunoglobulin E against 
      trimellityl-human serum albumin.
PG  - 869-73
AB  - The purpose of this study was to determine whether workers sensitized by one acid 
      anhydride, trimellitic anhydride (TMA), would possibly react immunologically to 
      two other acid anhydrides, phthalic anhydride (PA) or maleic anhydride (MA). We 
      studied serum samples from four workers with TMA asthma and immunoglobin E (IgE) 
      against TMA conjugated to human serum albumin (TM-HSA). In enzyme-linked 
      immunosorbent assay (ELISA) cross-inhibition studies, TM-HSA inhibited IgE 
      binding to TM-HSA, but when 100 times more P-HSA or M-HSA was used, no 
      significant inhibition occurred. However, in ELISA studies of P-HSA and M-HSA, we 
      saw binding of specific serum IgE. Finally, in passive transfer studies in rhesus 
      monkeys with serum from an individual with antibodies to all three acid 
      anhydrides, the following titers were obtained: TM-HSA (1:32), P-HSA (1:8), M-HSA 
      (negative). We conclude that cross-inhibition studies may not be the best method 
      for determining whether an individual sensitized to one antigen will react to a 
      related antigen. The determination of biologic reactivity in a rhesus monkey 
      model of passive cutaneous transfer makes it likely that biologic reactivity 
      would also occur in a human sensitized to TMA and then exposed to another 
      anhydride such as PA.
FAU - Lowenthal, M
AU  - Lowenthal M
AD  - Department of Medicine, Northwestern University Medical School, Chicago, IL 
      60611.
FAU - Shaughnessy, M A
AU  - Shaughnessy MA
FAU - Harris, K E
AU  - Harris KE
FAU - Grammer, L C
AU  - Grammer LC
LA  - eng
GR  - NIAID AI 11403/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - 0 (Maleic Anhydrides)
RN  - 0 (Phthalic Anhydrides)
RN  - 0 (Serum Albumin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 80T61EUU7H (trimellitic anhydride)
RN  - UVL263I5BJ (phthalic anhydride)
SB  - IM
MH  - Animals
MH  - Antibody Specificity
MH  - Asthma/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Macaca mulatta
MH  - Maleic Anhydrides/immunology
MH  - Occupational Diseases/*immunology
MH  - *Occupational Exposure
MH  - Phthalic Anhydrides/blood/*immunology
MH  - Serum Albumin/*immunology/metabolism
MH  - Skin Tests
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
PST - ppublish
SO  - J Lab Clin Med. 1994 Jun;123(6):869-73.