PMID- 8201269
OWN - NLM
STAT- MEDLINE
DCOM- 19940707
LR  - 20071114
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 123
IP  - 6
DP  - 1994 Jun
TI  - A naturally occurring model of immunoglobulin E antibody-mediated 
      hypersensitivity in laboratory animals.
PG  - 899-905
AB  - A naturally occurring model of immunoglobulin E (IgE) antibody-mediated 
      hypersensitivity in canine and rhesus monkey species to environmental allergens 
      is described. Cutaneous responses to a dust mite mix (Dermatophagoides 
      farinae/pteronyssinus) and to four storage mite extracts (Aleuroglyphus ovatus, 
      Blomia tropicalis, Chortoglyphus sp., Lepidoglyphus destructor) occurred in the 
      canine species. Rhesus monkeys had IgE antibody-mediated hypersensitivity to dust 
      mite on cutaneous challenge, but to a lesser degree than the canine species. 
      Biologic relevance was verified by eliciting positive airway challenges in both 
      species. The IgE antibody-mediated basis of these responses was confirmed by 
      passive transfer technique. Demonstration of dust mite allergy provides a 
      naturally occurring model of IgE antibody-mediated hypersensitivity in the canine 
      and rhesus monkey species. Storage mite IgE antibody-mediated hypersensitivity 
      exists in the canine species.
FAU - Hogan, M B
AU  - Hogan MB
AD  - Department of Medicine, Northwestern University Medical School, Chicago, IL 
      60611.
FAU - Harris, K E
AU  - Harris KE
FAU - Patterson, R
AU  - Patterson R
LA  - eng
GR  - AI 11403/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - 0 (Aerosols)
RN  - 0 (Allergens)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aerosols
MH  - Allergens/immunology
MH  - Animals
MH  - *Disease Models, Animal
MH  - Dogs
MH  - Dust
MH  - Female
MH  - Hypersensitivity/*immunology/physiopathology
MH  - Immunization, Passive
MH  - Immunoglobulin E/*immunology
MH  - Lung/physiopathology
MH  - Macaca mulatta
MH  - Male
MH  - Mites/immunology
MH  - Skin Tests
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
PST - ppublish
SO  - J Lab Clin Med. 1994 Jun;123(6):899-905.