PMID- 8201778
OWN - NLM
STAT- MEDLINE
DCOM- 19940705
LR  - 20190825
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 35
IP  - 1
DP  - 1994 Jan
TI  - Reduction of beta-adrenergic receptors in atrial cell membranes of patients 
      following mild to moderate heart failure.
PG  - 27-34
AB  - The density of cardiac beta-adrenoceptors (Bmax) was measured in eighteen 
      patients [2 with atrial septal defect (ostium secundum), 4 with aortic valve 
      disease, 3 with mitral valve disease, 1 with aortic and mitral valve disease, 5 
      with a history of myocardial infarction, and 3 with angina pectoris] following 
      mild to moderate cardiac failure. Measures were obtained by cardiac 
      catheterization prior to cardiac surgery and also during the surgical procedures. 
      On the basis of symptoms immediately preceding surgery, the severity of the 
      condition in each patient was categorized as either Class I (n = 5) or Class II 
      (n = 13) following the New York Heart Association (NYHA) functional 
      classification system. The Bmax was measured using right atrial appendage tissue 
      obtained during cardiac surgery. [125I]-iodocyanopindolol was used for the assay. 
      The Bmax of atrial cell membranes in patients with NYHA class II was 
      significantly lower than that of class I (34.1 +/- 2.5 vs 55.4 +/- 9.3 fmol/mg 
      protein, M +/- SE, p < 0.05). Correlation coefficients between the Bmax and 
      hemodynamic parameters measured just prior to cardiac surgery were examined, but 
      only that between Bmax and the minimum value of the time derivative of left 
      ventricular pressure (max negative dp/dt) was significant (r = -0.552, p < 0.05). 
      Further study is needed to understand and clarify the relationship between Bmax 
      and dp/dt min.
FAU - Ohsuzu, F
AU  - Ohsuzu F
AD  - Department of Medicine I, National Defense Medical College, Saitama, Japan.
FAU - Katsushika, S
AU  - Katsushika S
FAU - Akanuma, M
AU  - Akanuma M
FAU - Hakamada, N
AU  - Hakamada N
FAU - Hamada, H
AU  - Hamada H
FAU - Maie, S
AU  - Maie S
FAU - Muneoka, K
AU  - Muneoka K
FAU - Okumori, M
AU  - Okumori M
FAU - Nakamura, H
AU  - Nakamura H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
RN  - 0 (Receptors, Adrenergic, beta)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Catheterization
MH  - Female
MH  - Heart Atria/*chemistry
MH  - Heart Failure/complications/*metabolism/physiopathology
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Receptors, Adrenergic, beta/*analysis
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1536/ihj.35.27 [doi]
PST - ppublish
SO  - Jpn Heart J. 1994 Jan;35(1):27-34. doi: 10.1536/ihj.35.27.