PMID- 8203257
OWN - NLM
STAT- MEDLINE
DCOM- 19940707
LR  - 20190914
IS  - 0374-5600 (Print)
IS  - 0374-5600 (Linking)
VI  - 36
IP  - 2
DP  - 1994 Apr
TI  - Specific IgE antibodies and serum eosinophil cationic protein in children with 
      atopic dermatitis alone.
PG  - 146-9
AB  - Both eosinophils and specific immunoglobulin E (IgE) to foods and mites have been 
      considered involved in the pathogenesis of atopic dermatitis (AD). The 
      relationship between eosinophils and specific IgE, however, remains to be 
      elucidated. Blood eosinophil counts, serum eosinophil cationic protein (ECP) and 
      IgE to egg white, cow's milk, soybean, rice and Dermatophagoides pteronyssinus 
      (Dp) were measured in subjects with AD alone or bronchial asthma (BA) alone. 
      Subjects with positive IgE titers (Pharmacia radioallergosorbent test (RAST) 
      units > 0.7) of one or more items were defined as RAST-positive. Immunoglobulin E 
      titers to egg white, cow's milk and soybean of subjects with AD were high in 
      early childhood and declined with aging, whereas the titers of subjects with BA 
      were negative or low. Immunoglobulin E titers to Dp were elevated after 1 year of 
      age in both disease groups. Eosinophil cationic protein (ECP) levels and blood 
      eosinophil counts in the AD and BA groups were significantly higher than those of 
      non-atopic controls. No difference in ECP levels or blood eosinophil counts were 
      observed between RAST-positive and negative groups. It is concluded that IgE to 
      foods such as egg white, cow's milk and soybean might have a role in the 
      pathogenesis of AD of young children, while IgE to mites might be involved in 
      older children. Eosinophils may also participate in AD. However, different 
      mechanisms may be responsible for the rise in specific IgE and high ECP levels 
      and blood eosinophil counts.
FAU - Urisu, A
AU  - Urisu A
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Aichi, 
      Japan.
FAU - Kondo, Y
AU  - Kondo Y
FAU - Wada, E
AU  - Wada E
FAU - Horiba, F
AU  - Horiba F
FAU - Tsuruta, M
AU  - Tsuruta M
FAU - Yasaki, T
AU  - Yasaki T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Acta Paediatr Jpn
JT  - Acta paediatrica Japonica : Overseas edition
JID - 0370357
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adolescent
MH  - Blood Proteins/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*blood/*immunology
MH  - Eosinophil Granule Proteins
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Infant
MH  - *Ribonucleases
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.1111/j.1442-200x.1994.tb03150.x [doi]
PST - ppublish
SO  - Acta Paediatr Jpn. 1994 Apr;36(2):146-9. doi: 10.1111/j.1442-200x.1994.tb03150.x.