PMID- 8203332
OWN - NLM
STAT- MEDLINE
DCOM- 19940707
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 73
IP  - 16
DP  - 1994 Jun 15
TI  - Hemodynamic and metabolic correlates of dipyridamole-induced myocardial 
      thallium-201 perfusion abnormalities in multivessel coronary artery disease.
PG  - 1159-64
AB  - The mechanisms responsible for the development of reversible thallium-201 
      (TI-201) defects with dipyridamole stress in patients with coronary artery 
      disease (CAD) is not well understood. Previous experimental animal studies have 
      demonstrated coronary steal characterized by an absolute decrease in 
      subendocardial flow distal to a stenosis in response to dipyridamole infusion. 
      Accordingly, the purpose of this study was to determine if reversible TI-201 
      defects in response to dipyridamole infusion are reflective of myocardial 
      ischemia or secondary to regional differences in flow reserve. Dipyridamole (0.56 
      mg/kg) TI-201 imaging was performed in 23 patients in whom serial 
      electrocardiographic, hemodynamic, aortic and coronary sinus lactate, and 
      coronary sinus adenosine measurements were obtained. All patients with CAD had 
      TI-201 redistribution (3.8 +/- 2.0 defects/patient), and all patients without CAD 
      had normal scans. Mean aortic pressure was similar in both groups and did not 
      change in response to dipyridamole (non-CAD 103 +/- 11 vs CAD 99 +/- 15 mm Hg, p 
      = NS). Pulmonary capillary wedge pressure was similar at baseline (non-CAD 11 +/- 
      4 vs CAD 13 +/- 5 mm Hg, p = NS) and did not change in response to the drug 
      (non-CAD 14 +/- 3 vs CAD 15 +/- 7 mm Hg, p = NS). Lactate extraction fraction was 
      similar at baseline (non-CAD 0.22 +/- 0.09 vs CAD 0.17 +/- 0.14, p = NS) and 
      decreased similarly in both groups (non-CAD 0.08 +/- 0.06 vs CAD 0.05 +/- 0.12, p 
      = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - McLaughlin, D P
AU  - McLaughlin DP
AD  - Department of Medicine, University of Virginia Health Sciences Center, 
      Charlottesville.
FAU - Beller, G A
AU  - Beller GA
FAU - Linden, J
AU  - Linden J
FAU - Ayers, C R
AU  - Ayers CR
FAU - Ripley, M L
AU  - Ripley ML
FAU - Taylor, H
AU  - Taylor H
FAU - Watson, D D
AU  - Watson DD
FAU - Feldman, M D
AU  - Feldman MD
LA  - eng
GR  - R29HL47046-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Lactates)
RN  - 0 (Thallium Radioisotopes)
RN  - 64ALC7F90C (Dipyridamole)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/blood/metabolism
MH  - Blood Pressure/drug effects
MH  - Cohort Studies
MH  - Coronary Angiography
MH  - Coronary Circulation/*drug effects
MH  - Coronary Disease/diagnostic imaging/*physiopathology
MH  - Coronary Vessels/metabolism/physiopathology
MH  - *Dipyridamole
MH  - Electrocardiography/drug effects
MH  - Heart Rate/drug effects
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Lactates/blood
MH  - Myocardial Ischemia/diagnostic imaging/*physiopathology
MH  - Myocardium/*metabolism
MH  - Pulmonary Wedge Pressure/drug effects
MH  - Radionuclide Ventriculography
MH  - *Thallium Radioisotopes
EDAT- 1994/06/15 00:00
MHDA- 1994/06/15 00:01
CRDT- 1994/06/15 00:00
PHST- 1994/06/15 00:00 [pubmed]
PHST- 1994/06/15 00:01 [medline]
PHST- 1994/06/15 00:00 [entrez]
AID - 0002-9149(94)90174-0 [pii]
AID - 10.1016/0002-9149(94)90174-0 [doi]
PST - ppublish
SO  - Am J Cardiol. 1994 Jun 15;73(16):1159-64. doi: 10.1016/0002-9149(94)90174-0.