PMID- 8207119
OWN - NLM
STAT- MEDLINE
DCOM- 19940712
LR  - 20190825
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 52
IP  - 1
DP  - 1994 Jun
TI  - Increased levels of soluble tumor necrosis factor receptor in patients with 
      multiple sclerosis and HTLV-1-associated myelopathy.
PG  - 33-40
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a potent mediator produced by 
      activated T lymphocytes and macrophages, which may play a role in the 
      pathogenesis and development of multiple sclerosis (MS) and HTLV-1-associated 
      myelopathy (HAM). The first step in the induction of many biological effects 
      elicited by TNF-alpha is its binding to specific cell surface receptors. A 
      soluble form of TNF receptor (sTNF-R) can be detected in the body fluid. We 
      measured sTNF-R levels in the sera and cerebrospinal fluid (CSF) of patients with 
      either MS or HAM, and evaluated the correlation between this mediator and disease 
      activity. The levels of sTNF-R in the sera and CSF of patients with MS were 
      significantly increased compared with controls, particularly patients with acute 
      relapsing MS during an exacerbation (P < 0.001). CSF levels of sTNF-R showed a 
      strong correlation with those of TNF (r = 0.716, P < 0.001). Higher levels of 
      sTNF-R in the sera of HAM patients were detected as compared with those of either 
      controls (P < 0.001) or non-HAM carriers (P < 0.001). Patients with HAM exhibited 
      significantly higher CSF levels of sTNF-R than those with other neurological 
      diseases (P < 0.0001). These results suggest that the detection of sTNF-R in the 
      sera and CSF may predict disease progression. Availability of such a marker would 
      be useful in monitoring disease activity.
FAU - Matsuda, M
AU  - Matsuda M
AD  - Department of Medicine (Neurology), Shinshu University, School of Medicine, 
      Matsumoto, Japan.
FAU - Tsukada, N
AU  - Tsukada N
FAU - Miyagi, K
AU  - Miyagi K
FAU - Yanagisawa, N
AU  - Yanagisawa N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/blood/cerebrospinal fluid/*metabolism
MH  - Paraparesis, Tropical Spastic/blood/cerebrospinal fluid/*metabolism
MH  - Receptors, Tumor Necrosis Factor/*analysis
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1994/06/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 0165-5728(94)90159-7 [pii]
AID - 10.1016/0165-5728(94)90159-7 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1994 Jun;52(1):33-40. doi: 10.1016/0165-5728(94)90159-7.