PMID- 8207479
OWN - NLM
STAT- MEDLINE
DCOM- 19940711
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 14
IP  - 6
DP  - 1994 Jun
TI  - c-fos expression in vomeronasal pathways of mated or pheromone-stimulated male 
      golden hamsters: contributions from vomeronasal sensory input and expression 
      related to mating performance.
PG  - 3643-54
AB  - The vomeronasal system projects to the accessory olfactory bulb (AOB), to the 
      medial (Me) and posterior medial cortical nuclei (PMCN) of the amygdala, to the 
      bed nucleus of the stria terminalis (BNST), and to other central structures shown 
      to be important in mating behavior, including the medial preoptic area (MPOA). In 
      these experiments c-fos expression was used as a marker of neural activity to 
      identify the contribution of vomeronasal sensory input during mating behavior in 
      male golden hamsters, either intact or with vomeronasal organs removed (VNX). 
      Inexperienced hamsters were either stimulated with a receptive female and allowed 
      to mate, exposed to female hamster vaginal fluid (HVF), which contains stimuli 
      known to act through the VN system, or placed in a clean cage alone. Densely 
      stained Fos-positive nuclei were evident in mated animals in the central VN 
      pathway [AOB, Me, posterior medial BNST (pmBNST)] and a VN target area (MPOA). 
      HVF-exposed animals showed Fos expression in the AOB, Me, and BNST but not MPOA. 
      Unstimulated animals showed almost no activation. Most VNX animals exposed to 
      females did not mate, but performed intense chemoinvestigation. They had few 
      Fos-positive nuclei in any of these areas except the caudal pmBNST. A few VNX 
      animals that did mate had patterns of Fos activation that were similar but less 
      intense than those of intact mating animals, suggesting a selective activation of 
      VN central pathways during mating regardless of VN sensory input. The main 
      olfactory system showed low levels of Fos expression in all animals (stimulated 
      and unstimulated). Fos expression in the MPOA and rostral pmBNST was seen only in 
      mated animals, suggesting that these regions are concerned with mating 
      performance or its consequences, rather than the chemosensory input that triggers 
      it. Fos expression in the caudal encapsulated pmBNST was evident in all groups of 
      animals that performed chemosensory investigation, regardless of VN status or 
      mating, suggesting that this region either directs or responds to chemosensory 
      investigation.
FAU - Fernandez-Fewell, G D
AU  - Fernandez-Fewell GD
AD  - Department of Biological Science, Florida State University, Tallahassee 32306.
FAU - Meredith, M
AU  - Meredith M
LA  - eng
GR  - DC 00906/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Body Fluids/physiology
MH  - *Copulation
MH  - Cricetinae
MH  - Female
MH  - Male
MH  - Mesocricetus
MH  - Nasal Cavity/*innervation
MH  - Nasal Septum/*innervation
MH  - Neural Pathways/metabolism
MH  - Pheromones/*pharmacology
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Sensation/physiology
MH  - Sexual Behavior, Animal/physiology
MH  - Vagina/metabolism
PMC - PMC6576928
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
PMCR- 1994/12/01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
PHST- 1994/12/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.14-06-03643.1994 [doi]
PST - ppublish
SO  - J Neurosci. 1994 Jun;14(6):3643-54. doi: 10.1523/JNEUROSCI.14-06-03643.1994.