PMID- 8208763
OWN - NLM
STAT- MEDLINE
DCOM- 19940711
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 47
IP  - 3
DP  - 1994 Mar
TI  - Hypothalamic infusion of the 5-HT2/1C agonist, DOI, prevents the inhibitory 
      actions of the 5-HT1A agonist, 8-OH-DPAT, on lordosis behavior.
PG  - 467-70
AB  - Sexually receptive, intact, proestrous rats were infused bilaterally into the 
      ventromedial nucleus of the hypothalamus (VMN) with 200 ng of the 5-HT1A agonist, 
      8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), with 2000 ng of the 5-HT2/1C 
      agonist, (+/-)-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), or with 
      both 8-OH-DPAT and DOI. Alone, VMN infusions of 8-OH-DPAT, but not DOI, inhibited 
      lordosis behavior. When 2000 ng DOI was infused simultaneously with 8-OH-DPAT, 
      the inhibitory effects of 8-OH-DPAT were completely abolished. These results 
      suggest that neural sites responsible for the reported facilitatory effects of 
      5-HT2/1C agonists on lordosis behavior coexist in the VMN with those sites in 
      which 5-HT1A agonists are effective in reducing lordosis behavior. In contrast to 
      the protective action of the 5-HT2/1C receptor agonist following VMN infusion, no 
      protection was seen when both DOI and 8-OH-DPAT were administered 
      intraperitoneally. Thus, the interaction of these two receptor subtypes in the 
      control of lordosis behavior may be different in regions outside the VMN.
FAU - Uphouse, L
AU  - Uphouse L
AD  - Department of Biology, Texas Woman's University, Denton 76204.
FAU - Andrade, M
AU  - Andrade M
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - Maswood, S
AU  - Maswood S
LA  - eng
GR  - GM08256/GM/NIGMS NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage/*antagonists & 
      inhibitors/pharmacology
MH  - Amphetamines/administration & dosage/*pharmacology
MH  - Animals
MH  - Female
MH  - Injections
MH  - Injections, Intraperitoneal
MH  - Posture/*physiology
MH  - Proestrus/physiology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin Receptor Agonists/administration & dosage/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Ventromedial Hypothalamic Nucleus/anatomy & histology/*physiology
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 0091-3057(94)90144-9 [pii]
AID - 10.1016/0091-3057(94)90144-9 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1994 Mar;47(3):467-70. doi: 
      10.1016/0091-3057(94)90144-9.