PMID- 8209254
OWN - NLM
STAT- MEDLINE
DCOM- 19940712
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 264
IP  - 5166
DP  - 1994 Jun 17
TI  - The genetic basis of complex human behaviors.
PG  - 1733-9
AB  - Quantitative genetic research has built a strong case for the importance of 
      genetic factors in many complex behavioral disorders and dimensions in the 
      domains of psychopathology, personality, and cognitive abilities. Quantitative 
      genetics can also provide an empirical guide and a conceptual framework for the 
      application of molecular genetics. The success of molecular genetics in 
      elucidating the genetic basis of behavioral disorders has largely relied on a 
      reductionistic one gene, one disorder (OGOD) approach in which a single gene is 
      necessary and sufficient to develop a disorder. In contrast, a quantitative trait 
      loci (QTL) approach involves the search for multiple genes, each of which is 
      neither necessary nor sufficient for the development of a trait. The OGOD and QTL 
      approaches have both advantages and disadvantages for identifying genes that 
      affect complex human behaviors.
FAU - Plomin, R
AU  - Plomin R
AD  - Center for Developmental and Health Genetics, Pennsylvania State University, 
      University Park 16802.
FAU - Owen, M J
AU  - Owen MJ
FAU - McGuffin, P
AU  - McGuffin P
LA  - eng
GR  - HD-27694/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - *Genetics, Behavioral/methods
MH  - Humans
MH  - Mental Disorders/*genetics
MH  - *Mental Processes
MH  - Molecular Biology
MH  - Personality/*genetics
MH  - Social Environment
MH  - Twins/genetics
RF  - 62
EDAT- 1994/06/17 00:00
MHDA- 1994/06/17 00:01
CRDT- 1994/06/17 00:00
PHST- 1994/06/17 00:00 [pubmed]
PHST- 1994/06/17 00:01 [medline]
PHST- 1994/06/17 00:00 [entrez]
AID - 10.1126/science.8209254 [doi]
PST - ppublish
SO  - Science. 1994 Jun 17;264(5166):1733-9. doi: 10.1126/science.8209254.