PMID- 8211680
OWN - NLM
STAT- MEDLINE
DCOM- 19931108
LR  - 20220317
IS  - 0039-6060 (Print)
IS  - 0039-6060 (Linking)
VI  - 114
IP  - 4
DP  - 1993 Oct
TI  - Histocompatibility and liver transplantation.
PG  - 667-71; discussion 671-2
AB  - BACKGROUND: The role of histocompatibility between donor and recipient in liver 
      transplant rejection is unclear because of a paucity of data. The influence of 
      human leukocyte antigen (HLA) type on immunologic graft loss was examined for 
      primary liver transplantations performed at this center. METHODS: Immunologic 
      graft loss included patient death or retransplantation as a result of rejection 
      or impending graft loss caused by either late hepatic artery thrombosis or 
      severe, unremitting rejection requiring FK 506 rescue therapy. HLA A, B, and DR 
      matching was available on 205 donor-recipient combinations, and an additional 31 
      patients had A and B matching only. RESULTS: A mismatch of class I antigens (HLA 
      A and B) was predictive of immunologic graft loss (p = 0.018). DR mismatch did 
      not correlate with graft loss. When the A and B loci were analyzed separately, an 
      A mismatch correlated significantly with immunologic graft loss (p = 0.02), in 
      contrast to a B mismatch (p = 0.17). Better matching significantly improved 
      patient survival (p = 0.02) and overall graft survival (p = 0.009). CONCLUSIONS: 
      The beneficial effect of HLA class I antigen compatibility on liver 
      transplantation outcome is in contrast to pancreatic and kidney transplantation 
      in which class II antigen matching but not class I matching is beneficial. 
      Immunologic mechanisms of hepatic allograft rejection may differ from those 
      involved in kidney transplant rejection.
FAU - Knechtle, S J
AU  - Knechtle SJ
AD  - Department of Surgery, University of Wisconsin Hospital, Madison 53792.
FAU - Kalayolu, M
AU  - Kalayolu M
FAU - D'Alessandro, A M
AU  - D'Alessandro AM
FAU - Mason, B
AU  - Mason B
FAU - Pirsch, J D
AU  - Pirsch JD
FAU - Sollinger, H W
AU  - Sollinger HW
FAU - Steen, D C
AU  - Steen DC
FAU - Belzer, F O
AU  - Belzer FO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Forecasting
MH  - Graft Rejection/immunology
MH  - Graft Survival/immunology
MH  - HLA Antigens/immunology
MH  - *Histocompatibility
MH  - Histocompatibility Antigens Class I/immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Liver Transplantation
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 0039-6060(93)90253-A [pii]
PST - ppublish
SO  - Surgery. 1993 Oct;114(4):667-71; discussion 671-2.