PMID- 8213028
OWN - NLM
STAT- MEDLINE
DCOM- 19931029
LR  - 20190814
IS  - 0001-5172 (Print)
IS  - 0001-5172 (Linking)
VI  - 37
IP  - 6
DP  - 1993 Aug
TI  - Hemodynamic changes associated with thermodilution cardiac output determination 
      in canine acute blood loss or endotoxemia.
PG  - 602-6
AB  - Since the technique of thermodilution (TD) cardiac output measurement, per se, 
      causes hemodynamic alterations, the author examined whether the alterations 
      elicited by iced injectate are augmented in the presence of acute blood loss or 
      endotoxemia, compromised conditions frequently associated with critically ill 
      patients. Acute blood loss (N = 8) and endotoxemia (N = 8) were induced by 
      withdrawing arterial blood approximately 20-30 ml.kg-1 over 30 min and by a slow 
      intravenous infusion of E. coli endotoxin 2.5-3.0 mg.kg-1 over 10 min, 
      respectively, in anesthetized dogs. The magnitudes of decreases in mean arterial 
      and pulmonary artery pressures during slowing of heart rate (HR) following 
      injection of iced injectate 3 ml were slightly less in acute blood loss than in 
      normovolemia, whereas in endotoxemia the degree of mean arterial pressure 
      decrease during slowing of HR following iced injectate 3 ml was slightly less as 
      compared with that before endotoxemia. However, the alterations in other 
      hemodynamic variables following injection of iced injectate 3 ml were similar 
      between dogs with and without acute blood loss or endotoxemia. No profound 
      hemodynamic changes were observed during any TD cardiac output measurements under 
      both conditions. Cardiac output estimated by TD correlated closely with pulmonary 
      blood flow measured by electromagnetic flowmeter in endotoxemia (r > 0.9) but not 
      during acute blood loss. These results indicate that TD cardiac output 
      determination does not cause serious hemodynamic alterations in endotoxemia or 
      acute blood loss, and can estimate right ventricular output accurately in 
      endotoxemia but not in acute blood loss.
FAU - Nishikawa, T
AU  - Nishikawa T
AD  - Department of Anesthesiology, University of Tsukuba, Ibaraki, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
RN  - 0 (Bacterial Toxins)
RN  - 0 (Endotoxins)
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Acidosis/physiopathology
MH  - Animals
MH  - Atrial Function, Right/physiology
MH  - Bacterial Toxins/adverse effects
MH  - Blood Pressure/physiology
MH  - Carbon Dioxide/blood
MH  - Cardiac Output/*physiology
MH  - Dogs
MH  - Endotoxins/*adverse effects
MH  - Escherichia coli
MH  - Female
MH  - Heart Rate/physiology
MH  - Hemodynamics/*physiology
MH  - Hemorrhage/*physiopathology
MH  - Male
MH  - Oxygen/blood
MH  - Thermodilution
MH  - Toxemia/*physiopathology
MH  - Ventricular Function, Right/physiology
MH  - Ventricular Pressure/physiology
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 10.1111/j.1399-6576.1993.tb03773.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 1993 Aug;37(6):602-6. doi: 
      10.1111/j.1399-6576.1993.tb03773.x.