PMID- 8213910
OWN - NLM
STAT- MEDLINE
DCOM- 19931123
LR  - 20151119
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 47
IP  - 2
DP  - 1993 Aug 15
TI  - Clarification of subtle reciprocal rearrangements using fluorescence in situ 
      hybridization.
PG  - 223-30
AB  - Fluorescence in situ hybridization (FISH) using chromosome-specific DNA libraries 
      as painting probes was applied in the analysis of six subtle, balanced chromosome 
      rearrangements. Both fresh and older slides, some of which had been previously 
      G-banded, were used to determine if FISH could identify unambiguously very small 
      amounts of translocated material. Our results indicate that this procedure can 
      clearly and precisely distinguish the specific components of extremely subtle 
      translocations, in different cell types, such as leukocytes, aminocytes, and 
      chorionic villus, and irregardless of preparation age. This ability makes FISH a 
      valuable tool in clinical cytogenetics for the confirmation of preliminary 
      G-banded karyotypes.
FAU - Sullivan, B A
AU  - Sullivan BA
AD  - Department of Obstetrics and Gynecology, University of Maryland School of 
      Medicine, Baltimore.
FAU - Leana-Cox, J
AU  - Leana-Cox J
FAU - Schwartz, S
AU  - Schwartz S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (DNA Probes)
SB  - IM
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, Pair 22
MH  - Chromosomes, Human, Pair 4
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 8
MH  - Chromosomes, Human, Pair 9
MH  - DNA Probes
MH  - Female
MH  - Gene Library
MH  - Humans
MH  - In Situ Hybridization/*methods
MH  - Male
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
MH  - Sensitivity and Specificity
MH  - *Translocation, Genetic
EDAT- 1993/08/15 00:00
MHDA- 1993/08/15 00:01
CRDT- 1993/08/15 00:00
PHST- 1993/08/15 00:00 [pubmed]
PHST- 1993/08/15 00:01 [medline]
PHST- 1993/08/15 00:00 [entrez]
AID - 10.1002/ajmg.1320470217 [doi]
PST - ppublish
SO  - Am J Med Genet. 1993 Aug 15;47(2):223-30. doi: 10.1002/ajmg.1320470217.