PMID- 8214334
OWN - NLM
STAT- MEDLINE
DCOM- 19931123
LR  - 20190909
IS  - 0387-7604 (Print)
IS  - 0387-7604 (Linking)
VI  - 15
IP  - 2
DP  - 1993 Mar-Apr
TI  - Chronological SPECT studies of a patient with subacute sclerosing 
      panencephalitis.
PG  - 141-5
AB  - We describe here chronological single photon emission computed tomography (SPECT) 
      with N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) of a patient with subacute 
      sclerosing panencephalitis (SSPE) from the early clinical stages. The case, an 
      8-year-old Japanese girl, was in clinical stage I of the disease on admission. A 
      SPECT study with 99mTc-hexamethylprophyleamine oxime (99mTc-HM PAO) and 123I-IMP 
      revealed hypoperfusion of cerebral blood flow in the bilateral occipital areas 
      and a part of the cerebellum. Initially, no abnormal findings were observed on CT 
      and MRI. Subsequently, however, MRI indicated abnormal signal intensity 
      dominantly in the area of the occipital white matter where hypoperfusion of 
      cerebral blood flow was found by the initial SPECT studies. This abnormal 
      cerebral hypoperfusion appeared to improve after treatment with oral inosiplex 
      and intrathecal interferon-alpha over 6 months of the clinical course. The 
      abnormal signal intensity on the MRI also decreased, but simultaneous cranial CT 
      demonstrated diffuse cortical atrophy and slight ventricular dilatation.
FAU - Yagi, S
AU  - Yagi S
AD  - Department of Pediatrics, Kawasaki Medical School, Okayama, Japan.
FAU - Miura, Y
AU  - Miura Y
FAU - Mizuta, S
AU  - Mizuta S
FAU - Wakunami, A
AU  - Wakunami A
FAU - Kataoka, N
AU  - Kataoka N
FAU - Morita, T
AU  - Morita T
FAU - Morita, K
AU  - Morita K
FAU - Ono, S
AU  - Ono S
FAU - Fukunaga, M
AU  - Fukunaga M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (Amphetamines)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Oximes)
RN  - 3B744AG22N (Technetium Tc 99m Exametazime)
RN  - C2A5X08042 (Iofetamine)
SB  - IM
MH  - Amphetamines
MH  - Brain/diagnostic imaging/pathology
MH  - Child
MH  - Female
MH  - Humans
MH  - Iodine Radioisotopes
MH  - Iofetamine
MH  - Magnetic Resonance Imaging
MH  - Organotechnetium Compounds
MH  - Oximes
MH  - Subacute Sclerosing Panencephalitis/*diagnostic imaging/pathology
MH  - Technetium Tc 99m Exametazime
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - 0387-7604(93)90052-A [pii]
AID - 10.1016/0387-7604(93)90052-a [doi]
PST - ppublish
SO  - Brain Dev. 1993 Mar-Apr;15(2):141-5. doi: 10.1016/0387-7604(93)90052-a.