PMID- 8214357
OWN - NLM
STAT- MEDLINE
DCOM- 19931119
LR  - 20151119
IS  - 0192-8562 (Print)
IS  - 0192-8562 (Linking)
VI  - 15
IP  - 4
DP  - 1993 Nov
TI  - Tumor necrosis factor-alpha in malignant disease.
PG  - 364-9
AB  - PURPOSE: Due to its important role in immunoregulation, we have investigated 
      serum levels of tumor necrosis factor-alpha (TNF alpha), in children with newly 
      diagnosed, untreated, malignant disease. PATIENTS AND METHODS: These levels have 
      been related to the presence of infection and to the serum content of three other 
      cytokines, namely interleukin-1 beta, interleukin-2, and interferon-gamma. All 
      cytokine analyses were performed using highly sensitive radioimmunoassays. 
      RESULTS: Children with leukemia had higher mean levels of TNF alpha (63.6 +/- 
      12.3 pg/ml) than did children with solid tumors (21.5 +/- 4.2 pg/ml) and control 
      patients (10.5 +/- 2.6 pg/ml). TNF alpha levels in patients did not correlate 
      with the levels of the other cytokines or with the presence of infection. 
      CONCLUSIONS: Children with malignant disease often have elevated TNF alpha 
      levels. This elevation is dependent on the malignant disease process itself, and 
      could either reflect the host immunological response or tumor cell production of 
      TNF alpha.
FAU - Abrahamsson, J
AU  - Abrahamsson J
AD  - Department of Pediatrics I, University of Goteborg, Sweden.
FAU - Carlsson, B
AU  - Carlsson B
FAU - Mellander, L
AU  - Mellander L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pediatr Hematol Oncol
JT  - The American journal of pediatric hematology/oncology
JID - 7908071
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Biomarkers, Tumor/*blood
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Interferon-gamma/blood
MH  - Interleukin-1/blood
MH  - Interleukin-2/blood
MH  - Leukemia/*blood
MH  - Lymphoma/*blood
MH  - Neoplasms/*blood
MH  - Radioimmunoassay
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
PST - ppublish
SO  - Am J Pediatr Hematol Oncol. 1993 Nov;15(4):364-9.