PMID- 8219712
OWN - NLM
STAT- MEDLINE
DCOM- 19931207
LR  - 20061115
IS  - 0940-2993 (Print)
IS  - 0940-2993 (Linking)
VI  - 45
IP  - 4
DP  - 1993 Aug
TI  - Postnatal development of the rat CNS following in utero exposure to a low dose of 
      ionizing radiation.
PG  - 223-31
AB  - In utero exposure to ionizing radiation is of importance because of its potential 
      health risks. The developing nervous system is particularly vulnerable and the 
      consequences of exposure to low levels of radiation (< or = 1 Gy) are not well 
      established. The developmental effects of maternal exposure to 50 cGy 
      gamma-radiation on gestational days (GD) 9.5, 15, and 18 were investigated in 
      Sprague Dawley rats. Rats exposed on GD-9.5 along with appropriate controls were 
      killed at 4 h, 48 h, and 10 days post-irradiation while those irradiated on GD-15 
      and GD-18 were killed postnatally (PN) on days 7 and 26. All were examined for 
      developmental anomalies and representative samples of brains were processed for 
      microscopic study. No significant developmental differences were observed between 
      irradiated and control embryos killed 48 h after irradiation on GD 9.5. However, 
      in irradiated fetuses a larger number of developmental anomalies were observed at 
      term. Defects of the eye and of spinal curvature were the most common 
      malformations encountered. Mitoses were reduced within the neuroepithelium of 
      embryos irradiated on GD-9.5 and evidence of pyknosis and necrosis was seen 4 h 
      after irradiation. The capacity of surviving primitive neural cells for repair, 
      however, was such that by 48 h after exposure the irradiated nervous system no 
      longer differed from controls. Rats irradiated on GD-15 and GD-18 and examined on 
      PN-26 exhibited clusters of small, dark, pyknotic neurons within the hippocampal 
      and dentate gyri, often bilaterally.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Bruni, J E
AU  - Bruni JE
AD  - University of Manitoba, Department of Anatomy, Winnipeg, Canada.
FAU - Persaud, T V
AU  - Persaud TV
FAU - Huang, W
AU  - Huang W
FAU - Froese, G
AU  - Froese G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur 
      Toxikologische Pathologie
JID - 9208920
SB  - IM
MH  - Abnormalities, Radiation-Induced
MH  - Animals
MH  - Central Nervous System/pathology/*radiation effects
MH  - Cerebellum/pathology/radiation effects
MH  - Child, Preschool
MH  - Female
MH  - Fetus/*radiation effects
MH  - Hippocampus/pathology/radiation effects
MH  - Humans
MH  - Pregnancy
MH  - Radiation, Ionizing
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - S0940-2993(11)80395-7 [pii]
AID - 10.1016/S0940-2993(11)80395-7 [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 1993 Aug;45(4):223-31. doi: 10.1016/S0940-2993(11)80395-7.