PMID- 8222754
OWN - NLM
STAT- MEDLINE
DCOM- 19931215
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 65
IP  - 3
DP  - 1994
TI  - Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg 
      cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of 
      the locus.
PG  - 172-6
AB  - A novel 160-kDa intermediate filament associated protein, named restin 
      (Reed-Sternberg intermediate filament associated protein), is specifically 
      expressed in the malignant cells of Hodgkin's disease and anaplastic large cell 
      lymphoma (Ki-1 lymphoma). The combination of chromosomal R-banding and 
      fluorescence in situ hybridization (FISH) with the use of two fluorescent dyes, 
      fluorescein isothiocyanate and propidium iodide, allowed simultaneous detection 
      of the hybridized DNA sequence and chromosomal R-banding. By this technique, the 
      gene coding for restin (RSN) was assigned to chromosome region 12q24.31-->q24.33, 
      while localization of the alpha-2-macroglobulin receptor (A2MR) was refined to 
      12q13.1-->q13.3. To further analyze the restin gene, a 500-kb YAC clone 
      containing the gene was isolated and analyzed. A restriction map of this area is 
      presented.
FAU - Hilliker, C
AU  - Hilliker C
AD  - Center for Human Genetics, Katholieke Universiteit van Leuven, Belgium.
FAU - Delabie, J
AU  - Delabie J
FAU - Speleman, F
AU  - Speleman F
FAU - Bilbe, G
AU  - Bilbe G
FAU - Bruggen, J
AU  - Bruggen J
FAU - Van Leuven, F
AU  - Van Leuven F
FAU - Van den Berghe, H
AU  - Van den Berghe H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA, Complementary)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 148349-95-5 (cytoplasmic linker protein 170)
SB  - IM
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 12
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intermediate Filament Proteins/*genetics
MH  - *Microtubule-Associated Proteins
MH  - Neoplasm Proteins/*genetics
MH  - Reed-Sternberg Cells/*ultrastructure
MH  - Restriction Mapping
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1159/000133625 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1994;65(3):172-6. doi: 10.1159/000133625.