PMID- 8227726
OWN - NLM
STAT- MEDLINE
DCOM- 19931215
LR  - 20220317
IS  - 0342-4642 (Print)
IS  - 0342-4642 (Linking)
VI  - 19
IP  - 6
DP  - 1993
TI  - Pharmacokinetics of vancomycin during continuous hemodiafiltration.
PG  - 347-50
AB  - OBJECTIVE: To study the pharmacokinetics of vancomycin in three patients with 
      acute renal failure related to multi-organ failure during continuous venovenous 
      hemodiafiltration (CVVHD). DESIGN: Prospective exploratory, open-labelled study. 
      SETTING: Critical Care Unit in a University Medical Centre. PATIENTS: 3 patients 
      exhibiting hemodynamic instability and oligo-anuric acute renal failure requiring 
      extra-renal epuration were included in this study. INTERVENTION: Every patient 
      received 7.5 mg/kg IV vancomycin over 1 h for a documented or suspected 
      nosocomial staphylococcal infection. Serum and dialysate outlets samples were 
      collected before infusion and 1, 3, 6, 12, 18, 24 after the end of infusion. 
      MEASUREMENTS AND RESULTS: Mean age was 58.7 years (range 41-79) and mean SAPS 
      15.7 (9-23). The mean peak concentrations were 27.3 mg/l (range 15.6-45.6) one 
      hour after the end of infusion. The average remaining vancomycin concentration 24 
      h after the onset of infusion was 3.6 mg/l (range 2.6-4.5). The mean terminal 
      disposition rate constant and elimination half-life were 0.05 h-1 and 13.9 h 
      respectively. Mean total body clearance was 38.9 +/- 4.3 ml/min and dialysate 
      outlet (DO) clearance 4.2 +/- 1.3 ml/min. The mean volume of distribution was 
      47.4 +/- 6.4 l. CONCLUSION: CVVHD is effective for vancomycin elimination. In 
      these patients, the elimination half-life is almost constant, involving a 
      following injection of vancomycin 12 h later to achieve effective concentrations.
FAU - Santre, C
AU  - Santre C
AD  - Intensive Care and Infectious Diseases Unit, Hospital Centre, Tourcoing, France.
FAU - Leroy, O
AU  - Leroy O
FAU - Simon, M
AU  - Simon M
FAU - Georges, H
AU  - Georges H
FAU - Guery, B
AU  - Guery B
FAU - Beuscart, C
AU  - Beuscart C
FAU - Beaucaire, G
AU  - Beaucaire G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - 0 (Hemodialysis Solutions)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Acute Kidney Injury/epidemiology/metabolism/therapy
MH  - Adult
MH  - Aged
MH  - Critical Illness
MH  - France/epidemiology
MH  - Half-Life
MH  - *Hemodiafiltration/methods/statistics & numerical data
MH  - Hemodialysis Solutions/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Time Factors
MH  - Vancomycin/analysis/*pharmacokinetics
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1007/BF01694710 [doi]
PST - ppublish
SO  - Intensive Care Med. 1993;19(6):347-50. doi: 10.1007/BF01694710.