PMID- 8229208
OWN - NLM
STAT- MEDLINE
DCOM- 19931208
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 13
IP  - 11
DP  - 1993 Nov
TI  - Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations 
      of sensory neurons.
PG  - 4961-7
AB  - We have studied the effect of human recombinant neurotrophin-4/5 (NT-4/5) on the 
      survival of developing PNS neurons from embryonic mice and chickens. NT-4/5 
      transiently supported mouse NGF-dependent trigeminal and jugular neurons at early 
      stages of target field innervation and mouse brain-derived neurotrophic factor 
      (BDNF)-dependent no-dose neurons during the phase of naturally occurring cell 
      death. NT-4/5 was as potent as BDNF in supporting the survival of these neuronal 
      populations. Surprisingly, NT-4/5 was 3 orders of magnitude less potent than BDNF 
      as a survival factor for early chick dorsomedial trigeminal sensory neurons and 
      did not support the survival of chick BDNF-dependent trigeminal mesencephalic or 
      ventrolateral trigeminal sensory neurons at any of the developmental stages 
      tested. Thus, NT-4/5 is a survival factor for certain embryonic mouse cranial 
      sensory neurons. It is the first species-specific neurotrophin to be identified 
      and it can discriminate at high concentrations between different BDNF-responsive 
      chick neurons.
FAU - Davies, A M
AU  - Davies AM
AD  - School of Biological and Medical Sciences, St. Andrews University, Fife, 
      Scotland.
FAU - Horton, A
AU  - Horton A
FAU - Burton, L E
AU  - Burton LE
FAU - Schmelzer, C
AU  - Schmelzer C
FAU - Vandlen, R
AU  - Vandlen R
FAU - Rosenthal, A
AU  - Rosenthal A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 145172-44-7 (neurotrophin 5)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - CHO Cells
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Chick Embryo
MH  - Cricetinae
MH  - Dose-Response Relationship, Drug
MH  - Embryo, Mammalian
MH  - Ganglia/cytology
MH  - Humans
MH  - Kinetics
MH  - Mice
MH  - Nerve Growth Factors/biosynthesis/*pharmacology
MH  - Nerve Tissue Proteins/pharmacology
MH  - Neurons, Afferent/*cytology/drug effects
MH  - Recombinant Proteins/pharmacology
MH  - Transfection
MH  - Trigeminal Ganglion/cytology
PMC - PMC6576331
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
PMCR- 1994/05/01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
PHST- 1994/05/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.13-11-04961.1993 [doi]
PST - ppublish
SO  - J Neurosci. 1993 Nov;13(11):4961-7. doi: 10.1523/JNEUROSCI.13-11-04961.1993.