PMID- 8230332
OWN - NLM
STAT- MEDLINE
DCOM- 19931222
LR  - 20190711
IS  - 0022-5282 (Print)
IS  - 0022-5282 (Linking)
VI  - 35
IP  - 5
DP  - 1993 Nov
TI  - Serum tumor necrosis factor-alpha profile in trauma patients.
PG  - 698-702
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been implicated in several late 
      consequences of trauma such as sepsis, multiple organ failure, and 
      ischemia-reperfusion injury. However, no data are available to indicate whether 
      TNF-alpha is involved in the initial pathophysiologic response to trauma. To 
      address this issue, serum TNF-alpha was determined (by ELISA) longitudinally 
      (first blood sample on admission) in 100 randomly selected trauma patients 
      admitted to the emergency department and trauma division at Jefferson Medical 
      Center, Philadelphia. The TNF-alpha levels were detectable at one or more time 
      points in 35 patients. Mean values tended to be elevated (50.3 +/- 11.5 pg/mL) 
      during the first 5 days, but this trend did not differ statistically from that in 
      healthy controls (n = 12) and did not correlate with the severity of injury 
      (Injury Severity Score and Glasgow Coma Scale score). The TNF-alpha response was 
      not dependent on the mechanism and site of injury, the presence of shock 
      (systolic blood pressure < 90 mm Hg), and the need for emergent surgery. Also, 
      serum TNF-alpha levels were not significantly elevated in patients who 
      subsequently developed multiple organ failure (n = 4), septic shock (n = 5), or 
      both (n = 3). Taken together, these data do not support a role for circulating 
      TNF-alpha in the initial acute inflammatory response to trauma.
FAU - Rabinovici, R
AU  - Rabinovici R
AD  - Department of Surgery, Jefferson Medical College, Philadelphia, PA 19107.
FAU - John, R
AU  - John R
FAU - Esser, K M
AU  - Esser KM
FAU - Vernick, J
AU  - Vernick J
FAU - Feuerstein, G
AU  - Feuerstein G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Female
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Injury Severity Score
MH  - Longitudinal Studies
MH  - Male
MH  - Multiple Organ Failure/blood
MH  - Prospective Studies
MH  - Shock, Hemorrhagic/blood
MH  - Shock, Septic/blood
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - Wounds and Injuries/*blood
MH  - Wounds, Nonpenetrating/blood
MH  - Wounds, Penetrating/blood
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1097/00005373-199311000-00008 [doi]
PST - ppublish
SO  - J Trauma. 1993 Nov;35(5):698-702. doi: 10.1097/00005373-199311000-00008.