PMID- 8230805
OWN - NLM
STAT- MEDLINE
DCOM- 19931210
LR  - 20190920
IS  - 0021-5112 (Print)
IS  - 0021-5112 (Linking)
VI  - 46
IP  - 1
DP  - 1993 Feb
TI  - Two different histamine-sensitizing activities of pertussis vaccine observed in 
      mice on the 4th and 12th days of sensitization.
PG  - 17-27
AB  - The histamine-sensitizing (HS) activities of commercial precipitated 
      diphtheria-tetanus-purified pertussis combined vaccines (DTP) submitted to the 
      national quality control tests during the period from 1980 to 1991 were measured 
      in mice on days 4 (EHS) and 12 (LHS) of sensitization. Annual averages of the EHS 
      activity of the vaccines showed continuous decline during the period, while the 
      LHS activity stayed unchanged except for 1990 and 1991. Correlation analysis 
      between these two HS activities revealed that the vaccines could be 
      differentiated into two groups, those showing a significant correlation and those 
      lacking it, depending on their source manufacturers. When the vaccine was 
      incubated at 37 C for four weeks, both the HS activities increased for the first 
      couple of weeks at different rates, reaching their peaks after different periods; 
      three weeks for the EHS activity and two weeks for the LHS activity. Treating the 
      reference pertussis vaccine (for toxicity tests) with anti-pertussis toxin horse 
      serum neutralized completely the EHS activity but the LHS activity resisted the 
      serum. These findings suggest a possible difference between the two HS activities 
      in their mode of action, therefore, in their roles in possible reactogenicity of 
      the vaccine, and a necessity for separate controls of the two activities.
FAU - Horiuchi, Y
AU  - Horiuchi Y
AD  - Department of Safety Research on Biologics, National Institute of Health, Tokyo, 
      Japan.
FAU - Feng, D J
AU  - Feng DJ
FAU - Kameyama, S
AU  - Kameyama S
FAU - Takahashi, M
AU  - Takahashi M
FAU - Asada, S
AU  - Asada S
FAU - Asakawa, S
AU  - Asakawa S
FAU - Ishida, S
AU  - Ishida S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Jpn J Med Sci Biol
JT  - Japanese journal of medical science & biology
JID - 0243706
RN  - 0 (Diphtheria-Tetanus-Pertussis Vaccine)
RN  - 0 (Pertussis Vaccine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Diphtheria-Tetanus-Pertussis Vaccine/*immunology/standards
MH  - Female
MH  - *Histamine
MH  - *Immunization
MH  - Mice
MH  - Pertussis Vaccine/*immunology/standards
MH  - Quality Control
MH  - Reference Standards
MH  - Time Factors
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.7883/yoken1952.46.17 [doi]
PST - ppublish
SO  - Jpn J Med Sci Biol. 1993 Feb;46(1):17-27. doi: 10.7883/yoken1952.46.17.