PMID- 8239286
OWN - NLM
STAT- MEDLINE
DCOM- 19931210
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 695
DP  - 1993 Sep 24
TI  - Transgenic mice expressing human beta-APP751, but not mice expressing 
      beta-APP695, display early Alzheimer's disease-like histopathology.
PG  - 224-7
AB  - Mice transgenic for the 751 amino acid isoform of the human beta-amyloid 
      precursor protein (beta-APP) driven by the rat neuron specific enolase (NSE) 
      promoter (NSE:beta-APP751) show features of early Alzheimer's disease (AD) 
      pathology. These features, which were evident in multiple pedigrees, include: 1) 
      preamyloid deposits which stain with antibodies that are specific for the 
      beta-amyloid peptide and stain AD amyloid deposits and plaques, and 2) neuronal 
      soma and processes which stain with an antibody (Alz50) that detects abnormal 
      isoforms of tau which are characteristic of AD. The quality and distribution of 
      both types of immunoreactivity revealed in the NSE:beta-APP751 mouse brains most 
      closely resemble those seen in brains of young adults with Down's syndrome. Both 
      structures are rarely, if ever, observed in brains from mice transgenic for the 
      695 amino acid isoform of beta-APP (NSE:beta-APP695) or in wild type mice.
FAU - Higgins, L S
AU  - Higgins LS
AD  - Scios Nova Inc., Mountain View, California 94043.
FAU - Catalano, R
AU  - Catalano R
FAU - Quon, D
AU  - Quon D
FAU - Cordell, B
AU  - Cordell B
LA  - eng
GR  - R01 AG10655-01/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Aging/metabolism
MH  - Alzheimer Disease/metabolism/*pathology
MH  - Amyloid beta-Protein Precursor/*biosynthesis/genetics
MH  - Animals
MH  - Brain/metabolism/*pathology
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Phosphopyruvate Hydratase/genetics
MH  - Promoter Regions, Genetic
MH  - Rats
EDAT- 1993/09/24 00:00
MHDA- 1993/09/24 00:01
CRDT- 1993/09/24 00:00
PHST- 1993/09/24 00:00 [pubmed]
PHST- 1993/09/24 00:01 [medline]
PHST- 1993/09/24 00:00 [entrez]
AID - 10.1111/j.1749-6632.1993.tb23056.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1993 Sep 24;695:224-7. doi: 10.1111/j.1749-6632.1993.tb23056.x.