PMID- 8240231
OWN - NLM
STAT- MEDLINE
DCOM- 19931203
LR  - 20191210
IS  - 0264-6021 (Print)
IS  - 1470-8728 (Electronic)
IS  - 0264-6021 (Linking)
VI  - 295 ( Pt 2)
IP  - Pt 2
DP  - 1993 Oct 15
TI  - 9-cis-retinoic acid is a natural antagonist for the retinoic acid receptor 
      response pathway.
PG  - 343-6
AB  - The pleiotropic activities of retinoids are mediated by two types of nuclear 
      receptors, the retinoic acid receptors (RARs) and the retinoid X receptors 
      (RXRs). All-trans-retinoic acid (RA) transcriptionally activates RARs, but not 
      RXRs, whereas its natural stereoisomer, 9-cis-RA, is the ligand for RXRs. Here, 
      we demonstrate that 9-cis-RA did not transcriptionally activate RARs, whereas in 
      the presence of all-trans-RA the transactivation of RARs was inhibited in a 
      dose-dependent manner by 9-cis-RA. RAR homodimer complexes were destabilized in 
      vitro in the presence of 9-cis-RA. This suggests that 9-cis-RA may be a natural 
      antagonist of all-trans-RA for binding to RAR complexes. The levels of 9-cis-RA 
      may determine by which pathway the transcription of retinoid-responsive genes is 
      modulated.
FAU - Carlberg, C
AU  - Carlberg C
AD  - Clinique de Dermatologie, Hopital Cantonal universitaire, Geneve, Switzerland.
FAU - Saurat, J H
AU  - Saurat JH
FAU - Siegenthaler, G
AU  - Siegenthaler G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 0 (Receptors, Retinoic Acid)
RN  - 5688UTC01R (Tretinoin)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Chlorocebus aethiops
MH  - DNA/metabolism
MH  - Drosophila
MH  - Isomerism
MH  - Protein Biosynthesis
MH  - Receptors, Retinoic Acid/*antagonists & inhibitors/metabolism
MH  - Transcriptional Activation
MH  - Tretinoin/pharmacology
PMC - PMC1134887
EDAT- 1993/10/15 00:00
MHDA- 1993/10/15 00:01
PMCR- 1993/10/15
CRDT- 1993/10/15 00:00
PHST- 1993/10/15 00:00 [pubmed]
PHST- 1993/10/15 00:01 [medline]
PHST- 1993/10/15 00:00 [entrez]
PHST- 1993/10/15 00:00 [pmc-release]
AID - 10.1042/bj2950343 [doi]
PST - ppublish
SO  - Biochem J. 1993 Oct 15;295 ( Pt 2)(Pt 2):343-6. doi: 10.1042/bj2950343.