PMID- 8241509
OWN - NLM
STAT- MEDLINE
DCOM- 19940104
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 82
IP  - 11
DP  - 1993 Dec 1
TI  - Molecular genetics of myeloid leukemia: identification of the commonly deleted 
      segment of chromosome 20.
PG  - 3424-9
AB  - A deletion of the long arm of chromosome 20 [del(20q)] is a recurring abnormality 
      in malignant myeloid disorders. The occurrence of the del(20q) in a broad 
      spectrum of myeloid disorders suggests that the loss of genetic material on 20q 
      could provide a proliferative advantage to myeloid cells, possibly through the 
      loss of a tumor-suppressor gene. We have examined a series of patients with the 
      del(20q) using fluorescence in situ hybridization (FISH) with unique sequence 
      probes that map along the length of 20q, and have delineated a segment that is 
      deleted in 95% of all patients examined (18 of 19). In addition, we have shown 
      that the deletions are interstitial rather than terminal. This region of deletion 
      extends from 20q11.2 to q12, and is flanked by the RPN2 (proximal) and D20S17 
      loci (distal). The SRC and ADA genes are located within the commonly deleted 
      segment. Our findings emphasize the importance of FISH and other molecular 
      mapping techniques in defining such a region. The delineation of a commonly 
      deleted segment in 20q11.2-q12 will facilitate the identification of candidate 
      tumor-suppressor genes on 20q.
FAU - Roulston, D
AU  - Roulston D
AD  - Department of Medicine, University of Chicago Cancer Research Center, IL.
FAU - Espinosa, R 3rd
AU  - Espinosa R 3rd
FAU - Stoffel, M
AU  - Stoffel M
FAU - Bell, G I
AU  - Bell GI
FAU - Le Beau, M M
AU  - Le Beau MM
LA  - eng
GR  - CA40046/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 20
MH  - Female
MH  - Genes, src
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - S0006-4971(20)67954-X [pii]
PST - ppublish
SO  - Blood. 1993 Dec 1;82(11):3424-9.