PMID- 8242587
OWN - NLM
STAT- MEDLINE
DCOM- 19931230
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 70
IP  - 2
DP  - 1993 Oct 15
TI  - Identification of masked and variant Ph (complex type) translocations in CML and 
      classic Ph in AML and ALL by fluorescence in situ hybridization with the use of 
      bcr/abl cosmid probes.
PG  - 103-7
AB  - In the present study, three chronic myelogenous leukemia (CML) patients with 
      variant Philadelphia (Ph) chromosomes (complex types), two CML patients with a 
      masked Ph, one case with Ph positive acute lymphocytic leukemia (ALL), and one 
      with Ph positive acute myelocytic leukemia (AML) were analyzed by standard 
      cytogenetic techniques (G-banding), Southern blot studies, and fluorescence in 
      situ hybridization (FISH) procedures using probes from portions of the bcr and 
      abl genes. It has been previously shown that this FISH approach could detect the 
      bcr/abl fusion event in CML patients with classic or variant (simple type) Ph. 
      Our results demonstrate that this FISH assay can also detect the bcr/abl fusion 
      status in CML patients with masked or variant (complex type) Ph chromosomes and 
      in some patients with Ph positive ALL or AML.
FAU - Chen, Z
AU  - Chen Z
AD  - Cancer Center of Southwest Biomedical Research Institute and Genetrix, Inc., 
      Scottsdale, Arizona 85251.
FAU - Morgan, R
AU  - Morgan R
FAU - Berger, C S
AU  - Berger CS
FAU - Pearce-Birge, L
AU  - Pearce-Birge L
FAU - Stone, J F
AU  - Stone JF
FAU - Sandberg, A A
AU  - Sandberg AA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
GS  - abl
GS  - bcr
MH  - Adult
MH  - Aged
MH  - Blotting, Southern
MH  - *Chromosomes, Human, Pair 9
MH  - Cosmids
MH  - Female
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia/*genetics
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics
MH  - Leukemia, Myeloid, Acute/genetics
MH  - Male
MH  - Middle Aged
MH  - *Philadelphia Chromosome
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
MH  - *Translocation, Genetic
EDAT- 1993/10/15 00:00
MHDA- 1993/10/15 00:01
CRDT- 1993/10/15 00:00
PHST- 1993/10/15 00:00 [pubmed]
PHST- 1993/10/15 00:01 [medline]
PHST- 1993/10/15 00:00 [entrez]
AID - 0165-4608(93)90176-M [pii]
AID - 10.1016/0165-4608(93)90176-m [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1993 Oct 15;70(2):103-7. doi: 
      10.1016/0165-4608(93)90176-m.