PMID- 8242588
OWN - NLM
STAT- MEDLINE
DCOM- 19931230
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 70
IP  - 2
DP  - 1993 Oct 15
TI  - Cosmid mapping and locus linkage within the human chromosomal region 22q13.1.
PG  - 108-11
AB  - Many human meningiomas show loss of heterozygosity at distal loci but retain 
      constitutional heterozygosity at one or more proximal loci of 22q. Molecular 
      analysis indicted deletions involving at least the region 22q12.3-qter. In this 
      region, distal to myoglobin, the putative meningioma locus ought to be expected. 
      Long-range mapping was performed around two loci from 22q12.3-q13.1 (D22S16 and 
      PDGFB, the most proximal locus to be lost in meningioma). D22S16, originally 
      assigned to 22q13-qter by isotopic in situ hybridization, was placed in the 
      vicinity of PDGFB by utilizing a set of somatic cell hybrids, an assignment 
      confirmed by fluorescence in situ hybridization (FISH) of a cosmid clone 
      containing the D22S16 locus. Moreover, pulsed field gel electrophoresis suggests 
      a close linkage of both markers within 630 kb.
FAU - Blin, N
AU  - Blin N
AD  - Institut fur Anthropologie and Humangenetik, Univ. Tubingen, Germany.
FAU - Mullenbach, R
AU  - Mullenbach R
FAU - Suijkerbuijk, R
AU  - Suijkerbuijk R
FAU - Herzog, R
AU  - Herzog R
FAU - Meese, E
AU  - Meese E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-sis)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
GS  - sis
MH  - Arachnoid/cytology
MH  - Cells, Cultured
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 22/*ultrastructure
MH  - Cloning, Molecular
MH  - Cosmids
MH  - DNA, Neoplasm/analysis/isolation & purification
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - Gene Library
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - Meningeal Neoplasms/*genetics
MH  - Meningioma/*genetics
MH  - Platelet-Derived Growth Factor/genetics
MH  - Protein-Tyrosine Kinases/genetics
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins c-sis
MH  - Proto-Oncogenes
MH  - Tumor Cells, Cultured
EDAT- 1993/10/15 00:00
MHDA- 1993/10/15 00:01
CRDT- 1993/10/15 00:00
PHST- 1993/10/15 00:00 [pubmed]
PHST- 1993/10/15 00:01 [medline]
PHST- 1993/10/15 00:00 [entrez]
AID - 0165-4608(93)90177-N [pii]
AID - 10.1016/0165-4608(93)90177-n [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1993 Oct 15;70(2):108-11. doi: 
      10.1016/0165-4608(93)90177-n.