PMID- 8245704
OWN - NLM
STAT- MEDLINE
DCOM- 19940106
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 54
IP  - 6
DP  - 1993 Dec
TI  - Granulocyte-macrophage colony-stimulating factor plays a role in the functional 
      activity of mast cells.
PG  - 523-7
AB  - A peptide homologous to a region of murine granulocyte-macrophage 
      colony-stimulating factor (mGM-CSF), P27-38, which was shown to be a GM-CSF 
      antagonist, inhibited the function of serotonin release from murine mast cells. 
      Peptide P27-38 inhibited immunoglobulin E (IgE)-mediated serotonin release in a 
      dose-dependent manner when induced by either specific antigen or anti-IgE 
      antibody. In contrast, non-receptor-mediated release of serotonin by agents such 
      as compound 48/80 or the calcium ionophore A23187 were not affected by the GM-CSF 
      antagonist. Similar effects were observed with GM-CSF-neutralizing antibodies. 
      The inhibitory effect of P27-38 and the neutralizing antibodies on serotonin 
      release could be reversed by the addition of exogenous GM-CSF to the stimulated 
      mast cells, indicating that the inhibitory activity was probably due to an effect 
      on endogenously produced GM-CSF. These findings suggest that GM-CSF produced by 
      stimulated mast cells is involved in the regulation of their activity in an 
      autocrine manner.
FAU - Meade, R
AU  - Meade R
AD  - Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 
      06492-7660.
FAU - Neddermann, K M
AU  - Neddermann KM
FAU - Greenfield, R S
AU  - Greenfield RS
FAU - Braslawsky, G
AU  - Braslawsky G
FAU - Bursuker, I
AU  - Bursuker I
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Antibodies)
RN  - 0 (Peptide Fragments)
RN  - 333DO1RDJY (Serotonin)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/*physiology
MH  - Male
MH  - Mast Cells/*physiology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Molecular Sequence Data
MH  - Neutralization Tests
MH  - Peptide Fragments/pharmacology
MH  - Serotonin/metabolism
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1002/jlb.54.6.523 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1993 Dec;54(6):523-7. doi: 10.1002/jlb.54.6.523.