PMID- 8246986
OWN - NLM
STAT- MEDLINE
DCOM- 19940103
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 13
IP  - 12
DP  - 1993 Dec
TI  - Formation of retinoid X receptor homodimers leads to repression of T3 response: 
      hormonal cross talk by ligand-induced squelching.
PG  - 7698-707
AB  - Thyroid hormone receptors (TRs) form heterodimers with retinoid X receptors 
      (RXRs). Heterodimerization is required for efficient TR DNA binding to most 
      response elements and transcriptional activation by thyroid hormone. RXRs also 
      function as auxiliary proteins for several other receptors. In addition, RXR 
      alpha can be induced by specific ligands to form homodimers. Here we report that 
      RXR-specific retinoids that induce RXR homodimers are effective repressors of the 
      T3 response. We provide evidence that this repression by RXR-specific ligands 
      occurs by sequestering of RXR from TR-RXR heterodimers into RXR homodimers. This 
      ligand-induced squelching may represent an important mechanism by which 
      RXR-specific retinoids and 9-cis retinoic acid mediate hormonal cross talk among 
      a subfamily of nuclear receptors activated by structurally unrelated ligands.
FAU - Lehmann, J M
AU  - Lehmann JM
AD  - Cancer Center, La Jolla Cancer Research Foundation, California 92037.
FAU - Zhang, X K
AU  - Zhang XK
FAU - Graupner, G
AU  - Graupner G
FAU - Lee, M O
AU  - Lee MO
FAU - Hermann, T
AU  - Hermann T
FAU - Hoffmann, B
AU  - Hoffmann B
FAU - Pfahl, M
AU  - Pfahl M
LA  - eng
GR  - NCI CA 50676/CA/NCI NIH HHS/United States
GR  - NCI CA 51993/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (DNA, Complementary)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Binding, Competitive
MH  - Cell Line
MH  - DNA, Complementary/genetics/metabolism
MH  - Gene Expression/drug effects
MH  - HeLa Cells
MH  - Humans
MH  - Molecular Sequence Data
MH  - Protein Binding/drug effects
MH  - Protein Conformation
MH  - Rats
MH  - Receptors, Cytoplasmic and Nuclear/*chemistry/*drug effects/genetics
MH  - *Receptors, Retinoic Acid
MH  - Receptors, Thyroid Hormone/chemistry/genetics/metabolism
MH  - Retinoid X Receptors
MH  - *Transcription Factors
MH  - Tretinoin/pharmacology
MH  - Triiodothyronine/metabolism/*pharmacology
PMC - PMC364841
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
PMCR- 1993/12/01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
PHST- 1993/12/01 00:00 [pmc-release]
AID - 10.1128/mcb.13.12.7698-7707.1993 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1993 Dec;13(12):7698-707. doi: 10.1128/mcb.13.12.7698-7707.1993.