PMID- 8247360 OWN - NLM STAT- MEDLINE DCOM- 19940104 LR - 20190701 IS - 0304-3940 (Print) IS - 0304-3940 (Linking) VI - 160 IP - 2 DP - 1993 Oct 1 TI - Brain-derived neurotrophic factor expression after long-term potentiation. PG - 232-6 AB - Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization. FAU - Dragunow, M AU - Dragunow M AD - Department of Pharmacology, University of Auckland Medical School, New Zealand. FAU - Beilharz, E AU - Beilharz E FAU - Mason, B AU - Mason B FAU - Lawlor, P AU - Lawlor P FAU - Abraham, W AU - Abraham W FAU - Gluckman, P AU - Gluckman P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Nerve Tissue Proteins) RN - 0 (RNA, Messenger) RN - 6LR8C1B66Q (Dizocilpine Maleate) SB - IM MH - Animals MH - Brain/drug effects/*metabolism MH - Brain-Derived Neurotrophic Factor MH - Dizocilpine Maleate/pharmacology MH - Evoked Potentials/drug effects MH - Gene Expression/drug effects MH - In Situ Hybridization MH - *Long-Term Potentiation/drug effects MH - Male MH - Nerve Growth Factors/*biosynthesis MH - Nerve Tissue Proteins/*biosynthesis MH - RNA, Messenger/*biosynthesis MH - Rats MH - Rats, Sprague-Dawley EDAT- 1993/10/01 00:00 MHDA- 1993/10/01 00:01 CRDT- 1993/10/01 00:00 PHST- 1993/10/01 00:00 [pubmed] PHST- 1993/10/01 00:01 [medline] PHST- 1993/10/01 00:00 [entrez] AID - 0304-3940(93)90420-P [pii] AID - 10.1016/0304-3940(93)90420-p [doi] PST - ppublish SO - Neurosci Lett. 1993 Oct 1;160(2):232-6. doi: 10.1016/0304-3940(93)90420-p.