PMID- 8247537
OWN - NLM
STAT- MEDLINE
DCOM- 19931229
LR  - 20061115
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 8
IP  - 12
DP  - 1993 Dec
TI  - Translocation junctions cluster at the distal short arm of chromosome 1 
      (1p36.1-2) in human neuroblastoma cells.
PG  - 3353-8
AB  - Human neuroblastoma cells show at high frequency structural changes of the distal 
      short arm of chromosome 1 (1p). The commonly altered region has been identified 
      in previous loss-of-heterozygosity (LOH) studies to involve deletion of 1p36.1-2. 
      These bands are also the site of constitutional alterations in patients with 
      neuroblastoma. In an approach to define the 1p36.1-2 alterations in more detail 
      we here employ four neuroblastoma cell lines to map translocation breaks 
      involving 1p36.1-2 by fluorescence in situ hybridization (FISH). A chromosomal 
      interval flanked by loci DIS96 and DIS98 contained translocation junctions in 
      each of four lines. This analysis identifies in 1p a restricted genomic region as 
      involved in chromosomal rearrangement in different neuroblastomas. The 
      specificity of neuroblastoma translocation junctions at the molecular level 
      implicates this genomic region in tumor development.
FAU - Barker, P E
AU  - Barker PE
AD  - Department of Cytogenetics, German Cancer Research Center, Heidelberg.
FAU - Savelyeva, L
AU  - Savelyeva L
FAU - Schwab, M
AU  - Schwab M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
SB  - IM
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - Gene Rearrangement
MH  - Heterozygote
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Multigene Family/*genetics
MH  - Neuroblastoma/*genetics/pathology
MH  - Translocation, Genetic/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
PST - ppublish
SO  - Oncogene. 1993 Dec;8(12):3353-8.