PMID- 8252403
OWN - NLM
STAT- MEDLINE
DCOM- 19940113
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 624
IP  - 1-2
DP  - 1993 Oct 8
TI  - Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral 
      endotoxin treatment: comparison with interleukin-1 family and interleukin-6.
PG  - 291-4
AB  - The constitutive expression of tumor necrosis factor-alpha (TNF alpha) mRNA and 
      its induction (60 min later) by peripheral injection of Escherichia coli 
      lipopolysaccharide (2 mg/kg i.p.) was demonstrated by polymerase chain reaction 
      (PCR), in the pituitary and hypothalamus but not in the striatum or hippocampus 
      of the rat. The pattern of TNF alpha mRNA induction is different from that 
      observed for mRNAs of IL-1 alpha and IL-1 beta, IL-1ra and IL-6 respectively. 
      This demonstration of the induction of TNF alpha in the brain may contribute to 
      our understanding of the central effects of TNF alpha in fever and anorexia.
FAU - Gatti, S
AU  - Gatti S
AD  - Neurochemistry and Neurotoxicology Department, Stockholm University, Sweden.
FAU - Bartfai, T
AU  - Bartfai T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Endotoxins)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Oligonucleotide Probes)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Endotoxins/*pharmacology
MH  - Escherichia coli
MH  - Interleukin-1/*genetics
MH  - Interleukin-6/*pharmacology
MH  - Male
MH  - Molecular Sequence Data
MH  - Oligonucleotide Probes/genetics
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Tissue Distribution
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 1993/10/08 00:00
MHDA- 1993/10/08 00:01
CRDT- 1993/10/08 00:00
PHST- 1993/10/08 00:00 [pubmed]
PHST- 1993/10/08 00:01 [medline]
PHST- 1993/10/08 00:00 [entrez]
AID - 0006-8993(93)90090-A [pii]
AID - 10.1016/0006-8993(93)90090-a [doi]
PST - ppublish
SO  - Brain Res. 1993 Oct 8;624(1-2):291-4. doi: 10.1016/0006-8993(93)90090-a.