PMID- 8252632
OWN - NLM
STAT- MEDLINE
DCOM- 19940110
LR  - 20220311
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 75
IP  - 5
DP  - 1993 Dec 3
TI  - Abolition of anaphylaxis by targeted disruption of the high affinity 
      immunoglobulin E receptor alpha chain gene.
PG  - 969-76
AB  - Mast cells and basophils, which are activated by immunoglobulin E (IgE) and 
      allergen, play a prominent role in anaphylaxis. However, they express at least 
      three types of IgE receptor, including the high affinity IgE receptor (Fc epsilon 
      RI). The relative contribution of these IgE receptors, and possibly other 
      receptors such as Fc epsilon RII/CD23 and Mac-2, to the genesis of in vivo 
      anaphylaxis is still unclear. To address this question, we have generated Fc 
      epsilon RI-deficient mice. These mice appear normal and express a normal number 
      of mast cells, but they are resistant to cutaneous and systemic anaphylaxis. 
      These data demonstrate that Fc epsilon RI is necessary for the initiation of 
      IgE-dependent anaphylactic reactions. Therefore, interfering with its function 
      should be an effective means of treating allergy, regardless of the allergen 
      specificity.
FAU - Dombrowicz, D
AU  - Dombrowicz D
AD  - Molecular Allergy and Immunology Section, National Institute of Allergy and 
      Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852.
FAU - Flamand, V
AU  - Flamand V
FAU - Brigman, K K
AU  - Brigman KK
FAU - Koller, B H
AU  - Koller BH
FAU - Kinet, J P
AU  - Kinet JP
LA  - eng
GR  - R01 DK 46003-01/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, IgG)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Anaphylaxis/*immunology
MH  - Animals
MH  - B-Lymphocytes/metabolism
MH  - Base Sequence
MH  - DNA Primers/chemistry
MH  - Flow Cytometry
MH  - Mast Cells/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Mutagenesis, Insertional
MH  - Passive Cutaneous Anaphylaxis/*immunology
MH  - Receptors, IgE/*genetics/immunology/metabolism
MH  - Receptors, IgG/metabolism
MH  - Serotonin/metabolism
EDAT- 1993/12/03 00:00
MHDA- 1993/12/03 00:01
CRDT- 1993/12/03 00:00
PHST- 1993/12/03 00:00 [pubmed]
PHST- 1993/12/03 00:01 [medline]
PHST- 1993/12/03 00:00 [entrez]
AID - 0092-8674(93)90540-7 [pii]
AID - 10.1016/0092-8674(93)90540-7 [doi]
PST - ppublish
SO  - Cell. 1993 Dec 3;75(5):969-76. doi: 10.1016/0092-8674(93)90540-7.