PMID- 8255097
OWN - NLM
STAT- MEDLINE
DCOM- 19940107
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 7
IP  - 12
DP  - 1993 Dec
TI  - Whole arm translocation t(17;18): a non-random abnormality of myeloid cell 
      proliferation.
PG  - 1987-9
AB  - Whole arm translocation t(17;18) was detected in two patients, one with acute 
      monocytic leukemia and the other with acute transformation of chronic myelocytic 
      leukemia. Dual-color fluorescence in situ hybridization (FISH) to interphase 
      nuclei with alphoid probes specific to chromosomes 17 and 18 showed the presence 
      of two very close spots. This feature was interpreted as the conservation of the 
      pericentromeric region of the two chromosomes involved in the translocation. The 
      present cases add to eight previously reported other patients with whole arm 
      translocation t(17;18) (one with FISH studies). Since these patients had either 
      myeloid leukemia or myelodysplastic syndrome, it is suggested that the 
      t(17;18)(p10;q10) translocation is a new non-random abnormality associated with 
      myeloid cell proliferations.
FAU - Jonveaux, P
AU  - Jonveaux P
AD  - INSERM Unite 301 and SDI No. 15954 I CNRS, Institut de Genetique Moleculaire, 
      Paris, France.
FAU - Derre, J
AU  - Derre J
FAU - Berger, R
AU  - Berger R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Adult
MH  - Blast Crisis/genetics
MH  - Bone Marrow/*pathology
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 18
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Monocytic, Acute/*genetics
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
RF  - 8
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
PST - ppublish
SO  - Leukemia. 1993 Dec;7(12):1987-9.