PMID- 8258234
OWN - NLM
STAT- MEDLINE
DCOM- 19940119
LR  - 20220410
IS  - 0770-3198 (Print)
IS  - 0770-3198 (Linking)
VI  - 12
IP  - 3
DP  - 1993 Sep
TI  - Anti-Sm: its predictive value in systemic lupus erythematosus.
PG  - 350-3
AB  - The clinical manifestations of 131 rheumatic disease patients with anti-Sm 
      antibody were studied. A variety of standard tests was utilized in the study, 
      namely, the FANA test with mouse kidney as substrate for the assay of ANA, the 
      Crithidia test for anti-double stranded DNA (anti-dsDNA) and double 
      immunodiffusion for detecting antibodies to extractable nuclear antigens. The 
      patients were grouped according to the presence of anti-Sm alone, or anti-Sm with 
      some other antibodies. There were 17 with anti-Sm alone; 55 with 
      anti-Sm+anti-RNP; 15 with anti-Sm+anti-dsDNA; and 44 with anti-Sm+anti-RNP. The 
      result of our study showed that although anti-Sm could be found in other 
      diseases, it was exclusively detected in SLE only if anti-dsDNA was also present. 
      Further, the SLE patients with anti-Sm alone had more frequent central nervous 
      system manifestations than other groups of patients. The renal manifestation was 
      observed more frequently in the group of SLE patients with anti-Sm+anti-dsDNA 
      (92.9%). Among other major manifestations, haematologic involvement had a 
      tendency to be less common in the group of patients with anti-Sm alone. The study 
      concludes that the presence of anti-Sm antibody may be of some value to predict 
      the clinical outcome.
FAU - Janwityanuchit, S
AU  - Janwityanuchit S
AD  - Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Verasertniyom, O
AU  - Verasertniyom O
FAU - Vanichapuntu, M
AU  - Vanichapuntu M
FAU - Vatanasuk, M
AU  - Vatanasuk M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantigens)
RN  - 0 (Ribonucleoproteins, Small Nuclear)
RN  - 0 (snRNP Core Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antibodies, Antinuclear/*analysis
MH  - Autoantigens/*immunology
MH  - DNA/immunology
MH  - Humans
MH  - Lupus Erythematosus, Systemic/complications/diagnosis/*immunology
MH  - Predictive Value of Tests
MH  - Rheumatic Diseases/diagnosis/immunology
MH  - *Ribonucleoproteins, Small Nuclear
MH  - Skin Diseases/etiology
MH  - snRNP Core Proteins
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.1007/BF02231577 [doi]
PST - ppublish
SO  - Clin Rheumatol. 1993 Sep;12(3):350-3. doi: 10.1007/BF02231577.